Results 61 to 70 of about 452 (248)
Áttörés a kockázati mutatók validációjában – Megnyílt az út a várható többletveszteség effektív visszateszteléséhez? [PDF]
, 2019 Ez az írás egyfajta „figyelemfelhívás” kíván lenni a pénzügyi kockázati mutatók visszatesztelésében elért legújabb eredményekre. A téma a bankok által a kereskedési könyv portfóliókhoz szükséges minimális tőkeigényének meghatározásához használt belső ...
Bugár, Gyöngyi
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
On the Measurement of Economic Tail Risk
, 2015 This paper attempts to provide a decision-theoretic foundation for the measurement of economic tail risk, which is not only closely related to utility theory but also relevant to statistical model uncertainty.
Peng, Xianhua
core +2 more sources
Two-stage quadratic games under uncertainty and their solution by progressive hedging algorithms [PDF]
, 2019 A model of a two-stage N-person noncooperative game under uncertainty is studied, in which at the first stage each player solves a quadratic program parameterized by other players’ decisions and then at the second stage the player solves a recourse ...
Xu, Honglei, Zhang, M., Sun, Jie
core +2 more sources
Elicitability of range value at risk [PDF]
, 2019 The predictive performance of point forecasts for a statistical functional, such as the mean, a quantile, or a certain risk measure, is commonly assessed in terms of scoring (or loss) functions. A scoring functions should be (strictly) consistent for the
Fissler, Tobias, Ziegel, Johanna F
core
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Backtesting Expectiles with Moment Conditions [PDF]
, 2023 Under the current regulations, banks and insurance companies have the option to use their own internal models to monitor their risk. To this end, Value-at-Risk (VaR) and the Expected Shortfall (ES) are typically used as the risk measures to compute their
de Ita Solis, Jesús Armando
core +1 more source
, 2015 In the present contribution, under weak technical assumptions on the elicitability scoring function S we fully characterize the class of convex and coherent risk measures that are elicitable with an accuracy rewarding scoring function. In particular, we
Bellini, Fabio, BIGNOZZI, VALERIA
core +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source