Results 31 to 40 of about 12,330 (260)

Plant metabolic engineering strategies for the production of pharmaceutical terpenoids

Frontiers in Plant Science, 2016
Pharmaceutical terpenoids belong to the most diverse class of natural products. They have significant curative effects on a variety of diseases, such as cancer, cardiovascular diseases, malaria and Alzheimer’s disease.
Xu Lu, Kexuan Tang, Ping Li
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Resistência de plântulas de pepineiro a Colletotrichum lagenarium induzida por frações de extrato de Saccharomyces cerevisiae Resistance of cucumber seedlings to Colletotrichum lagenarium induced by fractions of Saccharomyces cerevisiae extract

Pesquisa Agropecuária Brasileira, 2009
O objetivo deste trabalho foi purificar frações do extrato de Saccharomyces cerevisiae que induzam a resistência do pepineiro a Colletorichum lagenarium e determinar sua eficiência na proteção de plântulas, em casa de vegetação. A suspensão de células da
Nívea Maria Tonucci Zanardo, Sérgio Florentino Pascholati, Maurício Batista Fialho   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Morpho‐physiological, productivity, and phytochemical responses of NIL‐Sletr1‐2 tomato mutants as an effect to different types of elicitors

Agrosystems, Geosciences & Environment
Near isogenic lines (NIL) were created to maintain good allele introgression in commercial tomatoes (Solanum lycopersicum). NIL‐Sletr 1‐2 mutant tomato has a long shelf life.
Arrin Rosmala, Imelda Marissa, Jajang Sauman Hamdani, Anne Nuraini, Bayu Pradana Nur Rahmat, Syariful Mubarok   +5 more
doaj   +1 more source

Additive and Specific Effects of Elicitor Treatments on the Metabolic Profile of Arabidopsis thaliana

Molecular Plant-Microbe Interactions
Several elicitors of plant defense have been identified and numerous efforts to use them in the field have been made. Exogenous elicitor treatments mimic the in planta activation of pattern-triggered immunity (PTI), which relies on the perception of ...
Lisa Cabre, Lun Jing, Moffat Makechemu, Kylhan Heluin, Sarah El Khamlichi, Jérôme Leprince, Marie Christine Kiefer-Meyer, Sylvain Pluchon, Jean-Claude Mollet, Cyril Zipfel, Eric Nguema-Ona   +10 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Electrophysiological Correlates of Amplified Emotion-Related Cognitive Processing Evoked by Self-Administered Disgust Images

Brain Sciences
In the processing of emotions, the brain prepares and reacts in distinctive manners depending upon the negative or positive nuance of the emotion elicitors.
Valentina Bianco, Annalisa Bello, Rocco Luca Cimmino, Giuliana Lucci, Elena Mussini, Rinaldo Livio Perri, Renato Borgatti, Francesco Di Russo   +7 more
doaj   +1 more source