Results 31 to 40 of about 12,697 (261)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Plant metabolic engineering strategies for the production of pharmaceutical terpenoids

Frontiers in Plant Science, 2016
Pharmaceutical terpenoids belong to the most diverse class of natural products. They have significant curative effects on a variety of diseases, such as cancer, cardiovascular diseases, malaria and Alzheimer’s disease.
Xu Lu, Kexuan Tang, Ping Li
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Morpho‐physiological, productivity, and phytochemical responses of NIL‐Sletr1‐2 tomato mutants as an effect to different types of elicitors

Agrosystems, Geosciences & Environment
Near isogenic lines (NIL) were created to maintain good allele introgression in commercial tomatoes (Solanum lycopersicum). NIL‐Sletr 1‐2 mutant tomato has a long shelf life.
Arrin Rosmala, Imelda Marissa, Jajang Sauman Hamdani, Anne Nuraini, Bayu Pradana Nur Rahmat, Syariful Mubarok   +5 more
doaj   +1 more source

Additive and Specific Effects of Elicitor Treatments on the Metabolic Profile of Arabidopsis thaliana

Molecular Plant-Microbe Interactions
Several elicitors of plant defense have been identified and numerous efforts to use them in the field have been made. Exogenous elicitor treatments mimic the in planta activation of pattern-triggered immunity (PTI), which relies on the perception of ...
Lisa Cabre, Lun Jing, Moffat Makechemu, Kylhan Heluin, Sarah El Khamlichi, Jérôme Leprince, Marie Christine Kiefer-Meyer, Sylvain Pluchon, Jean-Claude Mollet, Cyril Zipfel, Eric Nguema-Ona   +10 more
doaj   +1 more source

Resistência de plântulas de pepineiro a Colletotrichum lagenarium induzida por frações de extrato de Saccharomyces cerevisiae Resistance of cucumber seedlings to Colletotrichum lagenarium induced by fractions of Saccharomyces cerevisiae extract

Pesquisa Agropecuária Brasileira, 2009
O objetivo deste trabalho foi purificar frações do extrato de Saccharomyces cerevisiae que induzam a resistência do pepineiro a Colletorichum lagenarium e determinar sua eficiência na proteção de plântulas, em casa de vegetação. A suspensão de células da
Nívea Maria Tonucci Zanardo, Sérgio Florentino Pascholati, Maurício Batista Fialho   +2 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Electrophysiological Correlates of Amplified Emotion-Related Cognitive Processing Evoked by Self-Administered Disgust Images

Brain Sciences
In the processing of emotions, the brain prepares and reacts in distinctive manners depending upon the negative or positive nuance of the emotion elicitors.
Valentina Bianco, Annalisa Bello, Rocco Luca Cimmino, Giuliana Lucci, Elena Mussini, Rinaldo Livio Perri, Renato Borgatti, Francesco Di Russo   +7 more
doaj   +1 more source