Results 61 to 70 of about 33,113 (293)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Foliar Application of Methyl Jasmonate and Chitosan Improve Growth, Yield, and Quality of Guar (Cyamopsis tetragonoloba L.) Under Water-Deficit Stress

Plants
Guar (Cyamopsis tetragonoloba L.), a summer legume, is becoming increasingly important as an industrial crop due to its high gum and viscosity content. This study investigated the effects of methyl jasmonate (MeJA), chitosan (CH), and their combination ...
Sara Khurizadeh, Ruhollah Naderi, Heidar Meftahizadeh, Saeid Hazrati, Silvana Nicola   +4 more
doaj   +1 more source

Phytophthora megakarya and Phytophthora palmivora, closely related causal agents of cacao black pod rot, underwent increases in genome sizes and gene numbers by different mechanisms [PDF]

, 2017
Phytophthora megakarya (Pmeg) and Phytophthora palmivora (Ppal) are closely related species causing cacao black pod rot. Although Ppal is a cosmopolitan pathogen, cacao is the only known host of economic importance for Pmeg.
Ali, Shahin, Amoako-Attah, Ishmael, Bailey, Bryan, Begoude, Dider, Coulibaly, Klotioloma, Guiltinan, Mark J., Kronmiller, Brent A., Kébé, Boubacar Ismaël, Lary, David J., Meinhardt, Lyndel W., Melnick, Rachel L., Shao, Jonathan, Shen, Danyu, Strem, Mary, Ten Hoopen, Gerben Martijn, Tyler, Brett, Yaw Akrofi, Andrew   +16 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Impact of elicitors and light on biosynthesis of sesquiterpene lactones in tissue culture of Arnica montana and its variety Arbo

Frontiers in Plant Science
Arnica montana is a popular medicinal plant known for the sesquiterpene lactones (SLs) found in its flowers, which are valuable components in pharmacology and cosmetology. We present the application of in vitro culture of the species A.
Agata Parafiniuk, Agata Parafiniuk, Krystyna Kromer, Mariusz G. Fleszar, Mariusz G. Fleszar, Katarzyna Wróblewska, Jerzy Ł. Wiśniewski, Andrzej Gamian   +7 more
doaj   +1 more source

Control of Bremia lactucae in Field-Grown Lettuce by DL-3-Amino-n-Butanoic Acid (BABA) [PDF]

, 2007
DL-3-amino-n-butanoic acid (BABA) was effective in controlling downy mildew incited by Bremia lactucae Regel in lettuce plants. The two isomers of BABA, DL-2-amino-n-butanoic acid and 4-amino-butanoic acid and its s-enantiomer were ineffective compares ...
Baider, Alexander, Cohen, Yigal, Gotlieb, Dror, Rubin, Evgenia   +3 more
core  

Small RNA profiling reveals regulation of Arabidopsis miR168 and heterochromatic siRNA415 in response to fungal elicitors [PDF]

, 2014
Background: Small RNAs (sRNAs), including small interfering RNAs (siRNAs) and microRNAs (miRNAs), have emerged as important regulators of eukaryotic gene expression.
Baldrich, Patricia, Berger, Angélique, Garcia i Chapa, Meritxell, Kakar, Klementina, López-Moya, Juan José, Moreno, Ana Beatriz, Riechmann, José Luis, San Segundo, Blanca, Siré, Christelle   +8 more
core   +3 more sources

Defense response enhancement in strawberry via elicitors [PDF]

3 Biotech, 2016
في هذه الدراسة، تم إنشاء ثقافة تعليق الخلايا للفراولة (فراغاريا × أناسا)، وأصناف كاماروسا، وتشارلي الحلو. تم تحفيز الدشبذ الجنيني عن طريق حضانة أوراق اليافعين في المختبر على وسط، تحتوي على 2 ملغ/لتر من البيكلورام في الظلام. بدأت مزرعة التعليق من كالي الجنيني البالغ من العمر 4 أسابيع في وسط MS السائل مع 1 ملغ/لتر 2،4 - D و 2 ملغ/لتر بيكورام.
Gihan M. Hussein, Tarig Abdelrahman, Adel Hamdan Alwan   +2 more
openaire   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Profiling of altered metabolomic states in Nicotiana tabacum cells induced by priming agents.

Frontiers in Plant Science, 2016
Metabolomics has developed into a valuable tool for advancing our understanding of plant metabolism. Plant innate immune defenses can be activated and enhanced so that, subsequent to being pre-sensitized, plants are able to launch a stronger and faster ...
Msizi Innocent Mhlongo, Paul Anton Steenkamp, Paul Anton Steenkamp, Lizelle Ann Piater, Ntakadzeni Edwin Madala, Ian A Dubery   +5 more
doaj   +1 more source