Results 61 to 70 of about 127,505,457 (284)

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Addressing the eLearning contradiction: A collaborative approach for developing a conceptual framework learning object [PDF]

, 2005
In many universities there seems to be an “eLearning Contradiction” between the expressed need to integrate technology into the teaching-learning process and what is actually occurring in the majority of classrooms.
Terrie Lynn Thompson, Hinton, Chris, Carson, Brad, Bill Muirhead, Colla Jean Macdonald, Stodel, Emma, Erin Banit, Terrie Thompson, Thompson, Terrie Lynn, Banit, Erin, Muirhead, William, MacDonald, Colla J, Chris Hinton, Brad Carson, Emma Stodel   +14 more
core   +1 more source

أثر دفع التعارض على المسائل المتعلقة بمواقيت الحج وشروطه ومحظورات الإحرام The impact of conflict prevention on issues related to Hajj timings, conditions, and prohibitions in Ihram [PDF]

مجلة كلية الدراسات الإسلامية والعربية للبنات بدمنهور
هذه رسالة ماجستير بعنوان "أثر قواعد دفع التعارض على أحكام الحج دراسة فقهية مقارنة" للطالبة: ريم بنت محمد بن صالح الصقير. وقد احتوت هذه الرسالة على مقدمة وتمهيد بينت فيه قواعد دفع التعارض، وأقسامه، وأسبابه وشروطه، وفصلين، وخاتمة.  ويحتوي الفصل الأول على
ريم بنت محمد بن صالح الصقير, أحمد بن محمد الخليل   +1 more
doaj   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Lean digital education to resolve the paradox of the illusion of digital prosperity

Journal of Innovation & Knowledge
Digital education, including digitally supported education, is loaded with biases. Most participants are blinded by the abundance of digital devices and misled by the hardware and software providers who try to convince and force education systems to keep
Mária Csernoch
doaj   +1 more source

Data‐Driven Modeling of Composition–Processing–Microstructure Relations for Recycled Aluminum Cast Alloys

Advanced Science, EarlyView.
Interpretable machine learning reveals how composition and processing govern the formation and microstructural burden of Fe‐rich intermetallic compounds in recycled Al–Si–Fe–Mn alloys. By separating morphology selection from morphology‐conditioned burden partitioning, this framework shows that identical Fe contents can yield different intermetallic ...
Jaemin Wang, Waleed Mohammed, Dierk Raabe   +2 more
wiley   +1 more source

Experience‐Dependent Reorganization of Hippocampal CA3 Neuronal Ensembles Associates With Memory Generalization

Advanced Science, EarlyView.
Mice can transfer the learned rule of spatial working memory to guide similar but novel tasks. Hippocampal CA3 populational activity dynamically reorganize during memory generalization, shifting from task‐specific to generalized coding over testing days. Sparse yet redundant neural representations of CA3 enable rule transfer and cognitive map formation,
Da Song, Zilu Zhu, Yujun Deng, Yujie Song, Hui Li, Junjun Ni, Zhenzhen Quan, Yan Yan, Hong Qing   +8 more
wiley   +1 more source

Positive/Negative. Denial, Opposition, Contradiction

, 2020
Starting from an examination of the current meaning of “positive” and “negative”, the essay focuses on the impossibility of understanding the semantics of these terms through the concept of “relationship” and shows how their meaning is the same and ...
Mauro Visentin
core  

Evaluation of efficacy of iodine prophylaxis in Poland based on the examination of schoolchildren living in Opoczno Town (Lodz Voivodship)

Thyroid Research, 2012
Background In 1997 a currently obligatory model of iodine prophylaxis, based on mandatory iodization of household salt with 30 mg KI/kg, was introduced. The aim of our study was to assess the iodine intake among school-age children living in Opoczno in 3
Zygmunt Arkadiusz, Adamczewski Zbigniew, Wojciechowska-Durczyńska Katarzyna, Cyniak-Magierska Anna, Krawczyk-Rusiecka Kinga, Zygmunt Agnieszka, Karbownik-Lewińska Małgorzata, Lewiński Andrzej   +7 more
doaj   +1 more source

Engineering Synergistic Intra‐/Intermolecular Conformational Locking via Side‐Chain Branching: A β‐Sheet‐Inspired Strategy for Planar NIR‐II Phototheranostic Aggregates

Advanced Science, EarlyView.
A bio‐inspired side‐chain branching strategy is developed to orchestrate a dual noncovalent conformational locking (NoCL) network, enabling the construction of perfectly planar NIR‐II phototheranostic aggregates. Such structural precision maximizes light‐harvesting efficiency and optimizes exciton dynamics, ensuring synchronized enhancements in NIR‐II ...
Cheng Lu, Qian Jia, Bo Wu, Chao Li, Ryan T. K. Kwok, Tie‐Gen Chen, Jianwei Sun, Zheng Zhao, Teng‐Teng Chen, Zhongliang Wang, Jacky W. Y. Lam, Ben Zhong Tang   +11 more
wiley   +1 more source