Results 101 to 110 of about 2,298,074 (328)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Estimating the size of populations at risk for malaria: a case study in cattle herders and agricultural workers in Northern Namibia

Scientific Reports
Cattle herders and agricultural workers have been identified has key high-risk populations for malaria in northern Namibia. Population size estimates for these groups are lacking but are important for planning, monitoring and evaluating the effectiveness
Francois Rerolle, Jerry O. Jacobson, Cara Smith Gueye, Adam Bennett, Sidney Carrillo, Henry Ntuku, Jennifer L. Smith   +6 more
doaj   +1 more source

Artemisinin combination therapy mass drug administration in a setting of low malaria endemicity: programmatic coverage and adherence during an observational study in Zanzibar

Malaria Journal, 2017
Background Mass drug administration (MDA) appears to be effective in reducing the risk of malaria parasitaemia. This study reports on programmatic coverage and compliance of MDA using artemisinin-based combination therapy (ACT) in four shehias (smallest ...
Abdullah S. Ali, Narjis G. Thawer, Bakar Khatib, Haji H. Amier, Joseph Shija, Mwinyi Msellem, Abdul-wahid Al-mafazy, Issa A. Garimo, Humphrey Mkali, Mahdi M. Ramsan, Jessica M. Kafuko, Lynn A. Paxton, Richard Reithinger, Jeremiah M. Ngondi   +13 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

En-route to the ‘elimination’ of genotypic chloroquine resistance in Western and Southern Zambia, 14 years after chloroquine withdrawal

Malaria Journal, 2019
Background Anti-malarial resistance is, and continues to be a significant challenge in the fight against malaria and a threat to achieving malaria elimination.
Lungowe Sitali, Mulenga C. Mwenda, John M. Miller, Daniel J. Bridges, Moonga B. Hawela, Elizabeth Chizema-Kawesha, James Chipeta, Bernt Lindtjørn   +7 more
doaj   +1 more source

Old ideas to innovate tuberculosis control: preventive treatment to achieve elimination [PDF]

, 2013
Roland Diel, R. Loddenkemper, Jean-Pierre Zellweger, Giovanni Sotgiu, Lia D’Ambrosio, Rosella Centis, Marieke J. van der Werf, Masoud Dara, Anne Detjen, Peter Gondrie, Lee B. Reichman, Francesco Blasi, Giovanni Battista Migliori   +12 more
openalex   +1 more source

Peirce Island Pool Discharge Elimination [PDF]

, 2003
The Peirce Island Pool is owned by the City of Portsmouth and serves approximately 19,000 swimmers each summer. The pool was originally constructed in the 1930s and updated in the 1970s and again in the mid 1990s. The pool’s 800,000 gallons of water were
Landry, Natalie
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Feasibility and acceptability of multiple methods of recording injecting drug use episode data among people who inject drugs in Melbourne, Australia: a pilot evaluation study protocol

BMJ Open
Introduction Opioid overdose and blood-borne virus transmission are key health risks for people who inject drugs. Existing study methods that record data on injecting drug risks mostly rely on retrospective self-reporting that, while valid, are limited ...
Alexis Roth, Peter Higgs, Paul Dietze, Nick Scott, Daniel O’Keefe, Filip Djordjevic, Ashleigh Cara Stewart, Dylan Vella-Horne, Zoe Gleeson, Damian Pavlyshyn, Matthew Gill, Rebekka Petrovic, Ben Cocchiaro   +12 more
doaj   +1 more source

Shifting the burden or expanding access to care? Assessing malaria trends following scale-up of community health worker malaria case management and reactive case detection

Malaria Journal, 2017
Background Malaria is a significant burden to health systems and is responsible for a large proportion of outpatient cases at health facilities in endemic regions.
David A. Larsen, Anna Winters, Sanford Cheelo, Busiku Hamainza, Mulakwa Kamuliwo, John M. Miller, Daniel J. Bridges   +6 more
doaj   +1 more source