Results 111 to 120 of about 811,407 (258)

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

open access: yesAdvanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu   +8 more
wiley   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen   +20 more
wiley   +1 more source

RECENSIONE: Arturo MARZANO, Storia dei sionismi. Lo Stato degli Ebrei da Herzl a oggi, Roma, Carocci, 2017, 256 pp.

open access: yesDiacronie. Studi di Storia Contemporanea, 2018
Elisa TIZZONI (La Spezia, 1983), PhD in Storia contemporanea, ha svolto incarichi di ricerca ed insegnamento presso le Università di Firenze, Pisa, Nizza, Salisburgo e presso altre istituzioni culturali; nel 2017 ha ottenuto una Postgraduate Vibeke Sørensen Grant presso l’Historical Archives of the European Union a Firenze. Attualmente è visiting Fellow presso il Department of History and Civilization dell’Istituto Universitario Europeo di Firenze e Cultore della Materia presso il Dipartimento di Storia e Civiltà dell’Università di Pisa.
doaj  

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

open access: yesAdvanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng   +15 more
wiley   +1 more source

RECENSIONE: Catherine Brice, “Monarchie et identité nationale en Italie (1861-1900)”, Paris, Éditions de l’École des Hautes Études en Sciences Sociales, 2010, 432 p.

open access: yesDiacronie. Studi di Storia Contemporanea, 2011
Elisa MARCOBELLI ha compiuto i suoi studi in storia e filosofia tra la Ruprecht-Karls-Universität di Heidelberg e l’EHESS di Parigi. Presso quest’ultima istituzione ha conseguito, nell’ottobre 2010 il titolo di Master 2 con una tesi intitolata «Modifications intentionelles: la traduction comme filtre. Le cheminement des teste révisionnistes de la France et l’Allemagne jusqu’aux pages de la revue Critica sociale»; attualmente sta conseguendo la laurea magistrale presso l’Università di Heidelberg.
doaj  

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

open access: yesAdvanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang   +9 more
wiley   +1 more source

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