Results 61 to 70 of about 1,748,841 (287)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Ce que le numérique fait à l’historien.ne. Entretien avec Claire Lemercier

Diacronie. Studi di Storia Contemporanea, 2012
Émilien Ruiz est doctorant en histoire contemporaine à l’École des Hautes Études en Sciences Sociales (EHESS). Sa thèse Trop de fonctionnaires? La question des effectifs de l’État dans la France du XXe siècle porte sur divers aspects de l’évolution du ...
Elisa Grandi est doctorante en histoire contemporaine et histoire de l’Amérique Latine à l’Université Paris Diderot et membre du laboratoire SEDET. Sa thèse Réseaux Sociaux et changement institutionnel. Experts internationaux, médiation politique et reformes économiques en Colombie (1949-1966), sous la direction de Zacarias Moutoukias, porte sur les réseaux reliant les experts de la Banque Mondiale et le personnel local en Colombie lors des premières missions de la Banque dans le pays. Après avoir été Visiting Student à la Duke University et Visiting Scholar à la New School of Social Research, elle est actuellement boursière du Gouvernement français Eiffel-Excellence à l’Université Paris Diderot. Parmi ses publications: «David Lilienthal, la Banca Mondiale e lo sviluppo di una rete transnazionale di economic advising (1950-1957)», Diacronie. Studi di Storia Contemporanea: Storia transnazionale e prospettive transnazionali nell’analisi storica, N. 6, 2|2011 (URL: < http://www.studistorici.com/2011/05/01/grandi_numero_6/ >)., Émilien Ruiz est doctorant en histoire contemporaine à l’École des Hautes Études en Sciences Sociales (EHESS). Sa thèse Trop de fonctionnaires? La question des effectifs de l’État dans la France du XXe siècle porte sur divers aspects de l’évolution du nombre des fonctionnaires de l’État français des années 1880 aux années 1980. Il a enseigné la méthodologie de la recherche en histoire, l’histoire contemporaine et l’informatique pour les sciences historiques à l’EHESS et à l’Université Paris Diderot. Depuis janvier 2012, il est assistant de Paul-André Rosental à Sciences po (URL: < http://www.sciencespo.fr/ >). Il anime deux blogs scientifiques: “La Boite à Outils des Historiens”, avec Franziska Heimburger (URL: < http://www.boiteaoutils.info/ >), sur les outils informatique pour l’histoire; “Devenir historien-ne” (URL: < http://devhist.hypotheses.org/ >), sur la méthodologie de la recherche en histoire. Parmi ses publications: «Compter: l’invention de la statistique des fonctionnaires en France (années 1890-1930)», in BEZES, Philippe, JOIN-LAMBERT, Odile (dir.), «Comment se font les administrations», en Sociologie du Travail, 52, 2/2010, pp. 212-233.   +1 more
doaj  

Viruses incidence on yam (Dioscorea spp.) in five municipalities of sucre, colombia incidencia de virosis en ñame

Temas Agrarios, 2014
In Colombia, yams (Dioscorea spp.) are grown in the Caribbean region, with Dioscorea alata L. and Dioscorea rotundata Poir. most cultivated species. One of the limiting factors in these crops are diseases caused by viruses, especially by Potyvirus that ...
Iris R. Payares, Javier D. Beltrán, Euriel Millán   +2 more
doaj   +1 more source

Rapid Detection of Leishmania infantum Infection in Dogs: Comparative Study Using an Immunochromatographic Dipstick Test, Enzyme-Linked Immunosorbent Assay, and PCR [PDF]

, 2002
Current zoonotic visceral leishmaniasis (ZVL) control programs in Brazil include the culling of Leishmania infantum-infected reservoir dogs, a strategy that has failed to prevent a rise of canine and human ZVL cases over the past decade.
Bruce Alex, Bruce Alex, Clive R. Davies, Clive R. Davies, J. Clin Microbiol, Richard Reithinger, Richard Reithinger, Rupert J. Quinnell, Rupert J. Quinnell   +8 more
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

On boundedly generated subgroups of profinite groups

, 2014
In this paper we investigate the following general problem. Let $G$ be a group and let $i(G)$ be a property of $G$. Is there an integer $d$ such that $G$ contains a $d$-generated subgroup $H$ with $i(H)=i(G)$?
Covato, Elisa
core   +1 more source

Detection of pseudorabies virus antibody in swine oral fluid using a serum whole-virus indirect ELISA [PDF]

, 2020
Ting‐Yu Cheng, Alexandra Buckley, Albert Van Geelen, Kelly M. Lager, Alexandra Henao-Díaz, Korakrit Poonsuk, Pablo Piñeyro, David H. Baum, Ju Ji, Chong Wang, Rodger Main, Jeffrey J. Zimmerman, Luis G. Giménez‐Lirola   +12 more
openalex   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Assessment of the Psychometrical Properties of the Central Relationship Questionnaire 6.0 (CRQ 6.0) In HIV/Aids

Psicologia, 2009
HIV/Aids is a disease with physical and psychological consequences that can reach the affective-relationship field. The study aimed to evaluate the psychometric properties of the Central Relationship Questionnaire (CRQ 6.0) in seropositive HIV/Aids ...
Ariane Cristina Massei, Elisa Medici Pizão Yoshida   +1 more
doaj  

Evaluation of bio-conjugation methods for obtaining of synthetic positive control for IgM-capture ELISA

Regulatory Mechanisms in Biosystems, 2014
The enzyme-linked immunosorbent assay (ELISA) is the most informative and versatile method of serological diagnostics. The possibility of detecting by ELISA specific antibodies of different classes allow to differentiate primary infectious process and ...
O. Y. Galkin, Y. V. Gorshunov
doaj   +1 more source