Results 51 to 60 of about 990,809 (357)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Development of a Sandwich ELISA to Measure Exposure to Occupational Cow Hair Allergens [PDF]

, 2011
Background: Cow hair and dander are important inducers of occupational allergies in cattle-exposed farmers. To estimate allergen exposure in farming environments, a sensitive enzyme immunoassay was developed to measure cow hair allergens.
Angelika Flagge, Anne Spickenheuer, Berger I, Christina Fleischer, Dennis Nowak, Eva Zahradnik, Ferrer A, Heutelbeck AR, Hinze S, Hinze S, Ilka Noss, Ingrid Sander, Joachim Sültz, Krakowiak A, Krop EJ, Lydia Bruckmaier, Monika Raulf-Heimsoth, Noss I, Noss I, Prahl P, Prahl P, Prahl P, Radon K, Rautiainen J, Rautiainen J, Renstrom A, Restani P, Rudolf Schierl, Saarelainen S, Thomas Brüning, Virtanen T, Virtanen T, Virtanen T, Ylonen J, Ylonen J, Ylonen J, Zahradnik E   +36 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Development of a LAMP assay for detection of Leishmania infantum infection in dogs using conjunctival swab samples [PDF]

, 2015
Background: Leishmania infantum infections in dogs play a crucial role in the transmission of pathogens causing visceral leishmaniasis to humans in the Gansu province, northwest China. To be able to control zoonotic transmission of the parasite to humans,
A Moshfe, A Nasereddin, AF Koutinas, CH Gao, Chun-hua Gao, D Otranto, D Strauss-Ayali, Dan Ding, Dietmar Steverding, ER Adams, F Dantas-Torres, Feng Shi, G Schönian, H Kaneko, H Takagi, J Alvar, J Dereure, JM Lawrie, Jun-yun Wang, JY Wang, JY Wang, JY Wang, K Stuart, L Chamaillé, L He, L Solano-Gallego, LL Poon, LS Leontides, M Chaouch, M Gramiccia, M Paiva Cavalcanti de, MG Khan, N Chargui, N Kuboki, N Singh, P Ciaramella, RS Leite, S Reale, SA Ferreira, T Muccio Di, T Notomi, UG Lopes, WP Kennedy, X Ni, Xia Wang, Y Fichoux le, Y Mori, YM Gomes, Yue-tao Yang   +48 more
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

A noise simulator for eLISA: migrating LISA pathfinder knowledge to the eLISA mission [PDF]

, 2014
We present a new technical simulator for the eLISA mission, based on state space modeling techniques and developed in MATLAB. This simulator computes the coordinate and velocity over time of each body involved in the constellation, i.e.
Armano, M, Audley, H, Auger, G, Baird, J, Binetruy, P, Born, M, Bortoluzzi, D, Brandt, N, Bursi, A, Caleno, M, Cavalleri, A, Cesarini, A, Cruise, M, Danzmann, K, Diepholz, I, Dolesi, R, Dunbar, N, Ferraioli, L, Ferroni, V, Fitzsimons, E, Freschi, M, Gallegos, J, García Marirrodriga, C, Gerndt, R, Gesa, L I, Giardini, D, Gibert, F, Giusteri, R, Grimani, C, Harrison, I, Heinzel, G, Hewitson, M, Hollington, D, Hueller, M, Huesler, J, Inchauspé, H, Jennrich, O, Jetzer, P, Johlander, B, Karnesis, N, Kaune, B, Killow, C., Korsakova, N, Lloro, I, Maarschalkerweerd, R, Madden, S, Mance, D, Martin-Porqueras, F, Martín, V, Mateos, I, McNamara, P, Mendes, J, Mendes, L, Moroni, A, Nofrarias, M, Paczkowski, S, Perez, J A Romera, Perreur-Lloyd, M., Petiteau, A, Pivato, P, Plagnol, E, Prat, P, Ragnit, U, Ramos-Castro, J, Reiche, J, Robertson, D., Rozemeijer, H, Russano, G, Sarra, P, Schleicher, A, Slutsky, J, Sopuerta, C F, Sumner, T, Texier, D, Thorpe, J, Trenkel, C, Tu, H.B, Vetrugno, D, Vitale, S, Wanner, G, Ward, H., Waschke, S, Wass, P, Wealthy, D, Weber, W, Wen, S, Wittchen, A, Zanoni, C, Ziegler, T, Zweifel, P   +89 more
core   +6 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

NS1-based ELISA test efficiently detects dengue infections without cross-reactivity with Zika virus

International Journal of Infectious Diseases, 2021
Objectives: The aim of this study was to achieve greater specificity of dengue virus (DENV) serological tests based on a recombinant antigen derived from non-structural protein 1 (ΔNS1) with regard to cross-reactive Zika virus (ZIKV) anti-NS1 antibody ...
Samuel Santos Pereira, Robert Andreata-Santos, Lennon Ramos Pereira, Camila Pereira Soares, Alvina Clara Félix, Patrícia de Mello Jungmann Cardoso de Andrade, Edison Luís Durigon, Camila Malta Romano, Luís Carlos de Souza Ferreira   +8 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

DETERMINATION OF CANINE DIROFILARIASIS BY ELISA METHOD AND MODIFIED KNOTT'S TEST

Archives of Veterinary Medicine, 2009
Canine dirofilariasis is a parasitic disease. The causative agent is Dirofilaria immitis or Dirofilaria repens. It may appear as skin or as a heart disease.
Sara Savić, Živoslav Grgić, Biljana Vujkov, Ivan Fenjac, Dušan Pajković, Marina Žekić   +5 more
doaj   +1 more source