Results 151 to 160 of about 57,442 (306)

Mechanism‐informed machine learning for individualized tacrolimus dose adjustment in the early post‐kidney transplant period

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tacrolimus dosing in the early post‐kidney transplant period is challenging due to a narrow therapeutic index and substantial interindividual pharmacokinetic (PK) variability. This study aimed to develop and validate mechanism‐informed machine learning (ML) models to support individualized tacrolimus dosing during this critical period ...
Hui Yu, Zihan Qin, Logan S. Smith, Jeong M. Park, Hao‐Jie Zhu   +4 more
wiley   +1 more source

Princely graves from Kleinklein in Styria, Austria

Arheološki Vestnik, 2019
The princely graves in the Hartnermichelkogel 1 and 2, Pommerkogel and Kröllkogel tumuli form a burial ground separate from the rest of the Early Hallstatt necropolis located below the hillfort at Burgstallkogel near Kleinklein.
Markus Egg
doaj  

Tacrolimus exposure during pregnancy in kidney and liver transplantation recipients: A comparison between whole blood and plasma concentration‐to‐dose ratios

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tacrolimus monitoring is generally performed in whole blood (WB). Most (>85%) of circulating tacrolimus is bound to red blood cells. During pregnancy, WB monitoring might be suboptimal because of physiological changes including increased plasma volume and decreased haematocrit.
Jildau R. Meinderts, Paola Mian, Frederike G. I. van Vilsteren, Karien M. H. van de Wetering, Jelmer R. Prins, Stefan P. Berger, Daan J. Touw, Margriet F. C. de Jong   +7 more
wiley   +1 more source

Main factors associated with variability in the assessment of the objective response rate. A re‐analysis of the PHEREXA phase 3 clinical trial

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Local investigators (LIs) overestimate the objective response rate (ORR) in comparison to Blinded Independent Central Reviewers (BICR) in oncology. In this study, we re‐analysed data obtained in the PHEREXA trial (NCT01026142) with the following aims: i) to confirm at the single‐patient level the discrepancy observed by analysing ...
Gennaro Daniele, Tommaso Giovagnoli, Pierluigi Navarra, Cinzia Dello Russo   +3 more
wiley   +1 more source

‘Where are the adults?’: Troubling child‐activism and children's political participation

British Educational Research Journal, EarlyView.
Abstract Children's political participation is a well‐established theme in childhood studies. In this article we offer an original account of child activism that takes into account the entangled and emergent aspect of children as activists. We begin with a historical and a conceptual review, noting the importance of mid‐20th century developments such ...
Sharon Hunter, Claire Cassidy
wiley   +1 more source

Enhancing online MBA programmes: Student perceptions and key factors in programme design and delivery

British Educational Research Journal, EarlyView.
Abstract The demand for online business education continues to grow, driven by the need for innovative and adaptable learning pathways to attain an MBA. This study investigates student perceptions across three predominantly online MBA programmes at Imperial College in England, ESMT in Germany and Ivey Business School in Canada, aiming to delineate the ...
J. David M. Wood, Olivia de Paeztron, Nai Li, Josefine Raasch, Carin Peller‐Semmens, Lyn Purdy, Niko de Silva, Gavin Symonds   +7 more
wiley   +1 more source

A Late Bronze Age foreign elite? Investigating mobility patterns at Seddin, Germany. [PDF]

PLoS One
Frank AB, May J, Sabatini S, Schopper F, Frei R, Kaul F, Storch S, Hansen S, Kristiansen K, Frei KM.   +9 more
europepmc   +1 more source

A typology of schools across the four nations of the United Kingdom: Class, race and geography

British Educational Research Journal, EarlyView.
Abstract In this paper we analyse the hierarchical field of schools across the United Kingdom during the transition to university and suggest that there are five socially distinct clusters of schools. Our five‐cluster typology of UK schools is composed of an established group of elite private and state schools, schools for the white rural and suburban ...
Sol Gamsu, Håkan Forsberg
wiley   +1 more source

Ancient DNA from Shimao city records kinship practices in Neolithic China. [PDF]

Nature
Chen Z, Gardner JD, Sun Z, Bennett EA, Han Q, Pei X, Shao J, Shi H, Wang W, Xue J, Bai F, Dai X, He N, Guo X, Di N, Mao X, Liu T, Cao P, Liu F, Dai Q, Feng X, Ping W, Wu X, Zhang L, Chen L, Fu Q.   +25 more
europepmc   +1 more source

How can welfare regime and production regime theories explain differences in schools’ ability grouping policies? A comparative study using the PISA school survey

British Educational Research Journal, EarlyView.
Abstract Research evidence is mixed on the consequences of ability grouping policies, but most research has found an overrepresentation of disadvantaged social demographics in low‐ability groups. However, researchers have neglected to explain why ability grouping policies vary between countries.
Monica Reichenberg, Girma Berhanu, Lena Fridlund   +2 more
wiley   +1 more source