Results 241 to 250 of about 230,660 (338)

Amyloid Forming Human Lysozyme Intermediates are Stabilized by Non‐Native Amide‐π Interactions

Advanced Science, EarlyView.
Mutational variants of human lysozyme cause fatal systemic amyloidosis by depositing kilograms of protein in the viscera of patients. Central to this process is a partially unfolded protein intermediate state that initiates aggregation into amyloid fibrils.
Minkoo Ahn, Julian O. Streit, Christopher A. Waudby, Tomasz Włodarski, Angelo Miguel Figueiredo, John Christodoulou, Janet R. Kumita   +6 more
wiley   +1 more source

Assorted optical solitons of the (1+1)- and (2+1)-dimensional Chiral nonlinear Schrödinger equations using modified extended tanh-function technique. [PDF]

Sci Rep
Luo J, Manafian J, Eslami B, Mahmoud KH, Sharma R, Kumari N, Alsubaie AS.   +6 more
europepmc   +1 more source

Brachyury‐Activated Fucoidan Hydrogel Microspheres Rejuvenate Degenerative Intervertebral Discs Microenvironment

Advanced Science, EarlyView.
This study describes the creation of injectable Brachyury (Bry) mRNA‐loaded Fucoidan‐functionalized GelMA hydrogel microspheres (BLNP@GF). These microspheres efficiently suppress inflammation, enhance extracellular matrix (ECM) synthesis in degenerated nucleus pulposus cells, and mitigate intervertebral disc degeneration (IVDD) in rat models.
Yuhao Gong, Wenxiao Shi, Xingzhu Liu, Hang Yu, Yinghui Wu, Yanzhang Xia, Caichun Yue, Chongkai Yang, Cong Shen, Renjun Pei, Tianwen Xin, Hailong Pei, Jun Shen   +12 more
wiley   +1 more source

Chaotic behavior, sensitivity analysis and Jacobian elliptic function solution of M-fractional paraxial wave with Kerr law nonlinearity. [PDF]

PLoS One
Roshid MM, Safi Ullah M, Rahman MM, Roshid HO.   +3 more
europepmc   +1 more source

Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel 177Lu Nuclear Molecule Label

Advanced Science, EarlyView.
The study developed and validated a radionuclide‐labeled anti‐VGLUT1 antibody probe for the first nuclear imaging of cochlear spiral ganglion neurons (SGNs) in vivo. This approach may provide aid in screening candidates suitable for CI surgery by quantifying the number of surviving SGNs, and predicting the potential for postoperative hearing ...
Chenyang Kong, Xiaohui Wang, Jintao Yu, Li Wen, Chengwen Zheng, Ge Yin, Kai Xu, Weiwei He, Hao Wang, Xiaoli Lan, Dawei Jiang, Yu Sun   +11 more
wiley   +1 more source

Semantic Fusion Algorithm of 2D LiDAR and Camera Based on Contour and Inverse Projection. [PDF]

Sensors (Basel)
Yuan X, Liu Y, Xiong T, Zeng W, Wang C.
europepmc   +1 more source

Nasal Delivery of Engineered Exosomes via a Thermo‐Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair

Advanced Science, EarlyView.
Engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 reprogram glial cells to promote neuroprotection and neural regeneration following SCI. A chitosan‐based thermosensitive hydrogel enables sustained intranasal exosome delivery, bypassing systemic barriers and enhancing therapeutic efficacy.
Yangyang Wang, Jingsong Liu, Pengfei Li, Zhibin Peng, Yubo Zhang, Yishu Liu, Mi Li, Xuqiang Gong, Daqian Liu, Enze Xu, Hongbo Yang, Yuanliang Sun, Yan Xu, Yansong Wang   +13 more
wiley   +1 more source

Slowly Expanding Stable Dust Spacetimes. [PDF]

Arch Ration Mech Anal
Fajman D, Ofner M, Wyatt Z.
europepmc   +1 more source

Generalized Phase Tailoring of Arbitrary Orthogonal Polarizations in Meta‐Structure with High‐Order Geometric Symmetry

Advanced Science, EarlyView.
A generalized methodology is proposed for Cm (m ≥ 3) meta‐structures to achieve independent phase control of arbitrary orthogonal polarizations. By integrating orientation tuning with structural tailoring, this approach extends spin‐based designs to polarization‐diverse wavefront engineering, enabling multi‐functional and high‐efficiency meta‐devices ...
Kai Qu, Ke Chen, Qi Hu, Weixu Yang, Junming Zhao, Tian Jiang, Yijun Feng   +6 more
wiley   +1 more source

Modeling and simulation of blood flow in unhealthy elliptic arteries with computational fluid dynamics approach. [PDF]

PLoS One
Wahab A, Asjad MI, Riaz MB, Haider JA.
europepmc   +1 more source