Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells [PDF]
Pharmaceuticals, 2019 Ellipticines have well documented anticancer activity, in particular with substitution at the 1-, 2-, 6- and 9-positions. However, due to limitations in synthesis and coherent screening methodology the full SAR profile of this anticancer class has not ...
Charlotte M. Miller +2 more
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Synthesis and Evaluation of Novel Ellipticines and Derivatives as Inhibitors of Phytophthora infestans [PDF]
Pathogens, 2020 The pathogen Phytophthora infestans is responsible for worldwide catastrophic crop damage and discovery of new inhibitors of this organism is of paramount agricultural and industrial importance.
Mary L. McKee +6 more
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Ring D modifications of ellipticine. Part 1. New ellipticine derivatives from 1-cyano-6-methylellipticine. [PDF]
Tetrahedron, 1994 Abstract New ellipticine derivatives are synthesized by modification of the cyanogroup of 1-cyano-6-methylellipticine. This resulted in the information of 1-acetyl- and 1-acetamido-6-methylellipticine. Deprotonation of 1-cyano-6-methylellipticine under the influence of a Palladium catalyst leads to a new annelated ellipticine (9).
Boogaard, A.T. +2 more
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Hydrophobicity-enhanced ferritin nanoparticles for efficient encapsulation and targeted delivery of hydrophobic drugs to tumor cells. [PDF]
Protein Sci, 2023 Abstract Ferritin, a naturally occurring iron storage protein, has gained significant attention as a drug delivery platform due to its inherent biocompatibility and capacity to encapsulate therapeutic agents. In this study, we successfully genetically engineered human H ferritin by incorporating 4 or 6 tryptophan residues per subunit, strategically ...
Incocciati A +9 more
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DNA Intercalators Inhibit Eukaryotic Ribosomal RNA Synthesis by Impairing the Initiation of Transcription. [PDF]
Genes (Basel), 2021 In eukaryotes, ribosome biogenesis is driven by the synthesis of the ribosomal RNA (rRNA) by RNA polymerase I (Pol-I) and is tightly linked to cell growth and proliferation.
Andrews WJ +4 more
europepmc +3 more sources
Estrutura e propriedades de elipticinas Structure and properties of ellipticines
Química Nova, 2005 The ellipticines constitute a broad class of molecules with antitumor activity. In the present work we analyzed the structure and properties of a series of ellipticine derivatives in the gas phase and in solution using quantum mechanical and Monte Carlo ...
José J. V. Cirino +5 more
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Bone marrow stem cells incubated with ellipticine regenerate articular cartilage by attenuating inflammation and cartilage degradation in rabbit model. [PDF]
J Vet Sci, 2023 Hossain MA +8 more
europepmc +1 more source
Renal protective effect of ellipticine against streptozotocin induced diabetic nephropathy in rats via suppression of oxidative stress and inflammatory mediator. [PDF]
Acta Cir Bras, 2023 Li J +7 more
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9-Methoxyellipticine: Antibacterial Bioactive Compound Isolated from Ochrosia elliptica Labill. Roots. [PDF]
Metabolites, 2023 Elshimy R +4 more
europepmc +1 more source
Regulation of RNA Polymerase I Stability and Function. [PDF]
Cancers (Basel), 2022 Pitts S, Laiho M.
europepmc +1 more source