Anticancer and Immunomodulatory Activities of a Novel Water-Soluble Derivative of Ellipticine. [PDF]
Molecules, 2020 Cancer still remains a major public health concern around the world and the search for new potential antitumor molecules is essential for fighting the disease.
Costa de Oliveira R +7 more
europepmc +5 more sources
A Critical Analysis of the Impact of Etoposide as a Topoisomerase II Inhibitor in Cervical Cancer Treatment: A Review [PDF]
Cancer MedEtoposide mediated topoisomerase II inhibition in Cervical Cancer. ABSTRACT Background Etoposide is a semisynthetic derivative of podophyllotoxin and an FDA‐approved topoisomerase II inhibitor that induces DNA strand breaks leading to cancer cell death.
Kotian N, Reddy Y, Pai P, Sundara B.
europepmc +2 more sources
Synthesis of highly substituted diphenylacetamides and diphenylsulfonamides by the goldberg coupling reaction [PDF]
, 2000 We report the synthesis and characterisation of multisubstituted diphenylacetamides, diphenylsulfonamides and diphenylamines (and some observations on cyclisation of the last).Fundação para a Ciência e a Tecnologia (FCT)ICCTI and CRUP (Portugal) and the ...
Campos, Ana M. F. Oliveira +3 more
core +1 more source
Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context [PDF]
, 2012 The aryl hydrocarbon receptor (AhR) mediates the induction of a variety of xenobiotic metabolism genes. Activation of the AhR occurs through binding to a group of structurally diverse compounds, most notably dioxins, which are exogenous ligands ...
BALBONI, GIANFRANCO +10 more
core +1 more source
Advanced Science, Volume 10, Issue 35, December 15, 2023., 2023 An efficient free radical‐mediated photocyclization for triphenylphosphindole oxide derivatives to generate tribenzophosphindole oxide derivative is reported. Interestingly, this photo‐conversion can efficiently occur in living cells to activate photodynamic therapy and trigger fluorescence “light up” in lipid droplet area under continuous irradiation.
Jianqing Li +6 more
wiley +1 more source
Identification of New Drug Candidates Against \u3cem\u3eBorrelia burgdorferi\u3c/em\u3e Using High-Throughput Screening [PDF]
, 2016 Lyme disease is the most common zoonotic bacterial disease in North America. It is estimated that .300,000 cases per annum are reported in USA alone. A total of 10%–20% of patients who have been treated with antibiotic therapy report the recrudescence of
Babar, Mustafeez Mujtaba +9 more
core +3 more sources
Studies on 5-Bromo-4,7-dimethylindene, an intermediate in the synthesis of 6-Bromo-5,8-dimethylisoquinoline [PDF]
, 1999 We report the complete characterisation of all the precursors of 6-bromo-5,8-dimethylisoquinoline via Miller and Moock´s synthesis, and the synthesis of 6-bromo-4,7-dimethyl-2-(5´-Bromo-4´,7´-dimethyl)-2´,3´-dihydro-1´-H-inden-1´-yl)-1-H-indene.Fundação ...
Campos, Ana M. F. Oliveira +3 more
core +1 more source
Magnetic Resonance in Chemistry, Volume 61, Issue 11, Page 582-588, November 2023., 2023 This article presents the results of structure searches carried out starting from 58 carbon‐13 NMR data sets recorded on pure organic natural products selected in the Biological Magnetic Resonance Bank (BMRB). Two structural dereplication methods were employed. They proved to be efficient and can be used together in a complementary way.
Jean‐Marc Nuzillard
wiley +1 more source
Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint [PDF]
, 2018 Summary Inhibition of RNA polymerase I (Pol I) is a promising strategy for modern cancer therapy. BMH-21 is a first-in-class small molecule that inhibits Pol I transcription and induces degradation of the enzyme, but how this exceptional response is ...
Kucerova, Alena +6 more
core +2 more sources
Two preclinical tests to evaluate anticancer activity and to help validate drug candidates for clinical trials. [PDF]
, 2015 Current approaches to assessing preclinical anticancer activity do not reliably predict drug efficacy in cancer patients. Most of the compounds that show remarkable anticancer effects in preclinical models actually fail when tested in clinical trials. We
López Lázaro, Miguel
core +2 more sources