Results 21 to 30 of about 537 (162)

Novel synthetic routes to thienocarbazoles via palladium or copper catalyzed amination or amidation of arylhalides and intramolecular cyclization [PDF]

, 2002
Palladium or copper catalyzed aminations or amidations were performed to obtain diarylamines and diarylacetamides precursors of thienocarbazoles. The fact that an ortho-bromodiarylamine didn’t cyclize to the corresponding thienocarbazole under conditions
Cagniant, Cagniant, Chakraborty, Dalton, Dougherty, Ferreira, Freeman, Gilbert Kirsch, Ihmels, Isabel C.F.R Ferreira, Iwaki, Knölker, Knölker, Maria-João R.P Queiroz, Ostrovidov, Patani, Peixoto, Pierre, Pierre, Rosseau-Richard, Thornerm, Wolfe   +21 more
core   +2 more sources

The identification of a novel role for BRCA1 in regulating RNA Polymerase I transcription [PDF]

, 2016
The unrestrained proliferation of cancer cells requires a high level of ribosome biogenesis. The first stage of ribosome biogenesis is the transcription of the large ribosomal RNAs (rRNAs); the structural and functional components of the ribosome ...
Anderes, Ashworth, Avraham, Bishop, Bliesath, Blomqvist, Boulton, Boultwood, Bunz, Casellas, Chiba, Chiba, Chiba, Deng, Ellis, Felsher, Fingar, Folk, Foulkes, Grummt, Grummt, Grummt, Grummt, Grummt, Hannan, Harkin, Harkin, Harkin, Jackson, Johnston, Kaisho, Kruk, Lane, Langst, Leadon, Lee, Lee, Livingston, Lu, Ma, McStay, Moss, Pandolfi, Panov, Parvin, Parvin, Parvin, Parvin, Pearson, Roberts, Rosen, Rothblum, Sanij, Schelfhout, Schneider, Schramm, Shiekhattar, Shimizu, Shore, Stefanovsky, Tao, Thompson, Thompson, Vaux, Warner, White, White, White, Wright, Xia, Yang, Zomerdijk, Zomerdijk, Zomerdijk, Zomerdijk, Zou   +75 more
core   +2 more sources

Clinical relevance of P-glycoprotein expression in haematological malignancies [PDF]

, 1994
Although, generally speaking, haematological malignancies are chemotherapy-responsive tumours and high remission induction rates are obtained, disease-related death is the rule rather than the exception.
Nooter, K. (Kees), Sonneveld, P. (Pieter)   +1 more
core   +2 more sources

Influence of oxidative stress on aryl hydrocarbon receptor signaling [PDF]

, 2013
The aryl hydrocarbon receptor (AHR), a multifunctional protein and a key regulator of drug metabolizing enzymes, belongs to the basic-helix-loop-helix (bHLH)/PAS (Per- Arnt-Sim) super-family of transcription factors.
Mohammadi Bardbori, Afshin
core   +1 more source

Synthesis and biological evaluation of novel folic acid receptor-targeted, β-cyclodextrin-based drug complexes for cancer treatment [PDF]

, 2013
Drug targeting is an active area of research and nano-scaled drug delivery systems hold tremendous potential for the treatment of neoplasms. In this study, a novel cyclodextrin (CD)-based nanoparticle drug delivery system has been assembled and ...
Duan, Wei, Guo, Peixuan, Jia, Lee, Kanwar, Jagat R., Li, Chen-Zhong, Li, Qi, Li, Xiaotian, Liang, Jun, Liu, Wanqing, Mohapatra, Shyam S., Sharma, Sonali, Shumyak, Stepan P., Tan, Jun, Wang, Jian-Cheng, Wang, Zhi-Xin, Wei, Ming Q., Yang, Tianxin, Yin, Juan-Juan, Zhang, Xueji, Zhang, Yangde, Zhou, Shu-Feng, Zhou, Zhi-Wei   +21 more
core   +5 more sources

N-thioalkylcarbazoles derivatives as new antiproliferative agents: synthesis, characterisation and molecular mechanism evaluation [PDF]

, 2018
Synthetic or natural carbazole derivatives constitute an interesting class of heterocycles, which showed several pharmaceutical properties and occupied a promising place as antitumour tools in preclinical studies.
and Maria Rosaria Plutino, Anna Caruso, Camillo Rosano, Carmela Saturnino, Domenico Iacopetta, Francesco Puoci, Jessica Ceramella, Manuela Rodriquez, Maria Stefania Sinicropi, Noemi Muia, Pasquale Longo, Rosario Randino   +11 more
core   +2 more sources

Multigram scale synthesis of polycyclic lactones and evaluation of antitumor and other biological properties [PDF]

, 2022
An efficient four-step synthesis of tetracyclic lactones from 1,4-benzodioxine-2-carboxylic acid was developed. Ellipticine derivatives exhibit antitumor activity however only a few derivatives without carbazole subunit have been studied to date. Herein,
Grau, Laura, Morral, Jordi, Pors, Klaus, Presa, Daniela, Privat-Contreras, Cristian, Pujol Dilmé, M. Dolors, Romero, Manel, Rubio Martínez, Jaime, Viñas, Miquel   +8 more
core   +1 more source

From Synthesis to Therapeutics: Bioactive‐Coated Zein Nanoparticles in Drug Delivery

Biopolymers, Volume 117, Issue 2, March 2026.
ABSTRACT Polymeric zein nanoparticles (ZNP), derived from corn protein, are biodegradable drug carriers with high stability and low synthesis costs. Their amphiphilic nature allows efficient encapsulation of both hydrophilic and lipophilic drugs, making them promising for drug delivery.
Milena Ferreira de Lima, Andy Joel Taipe Huisa, Azael da Silva Neto, Clarice Beatriz Gonçalves Silva, Iago Dillion Lima Cavalcanti, Karolliny Barbosa de Araújo, Mariane Cajubá de Britto Lira‐Nogueira, Nereide Stela Santos Magalhães, Priscila Gubert   +8 more
wiley   +1 more source

Exploration of Antiplasmodium Chemical Space Identifies New Inhibitors of β‐Hematin Formation from Areas of Enrichment

ChemMedChem, Volume 21, Issue 3, 12 February 2026.
An enrichment map, developed using principal components analysis (PCA), shows the relative abundance of inhibitors of synthetic hemozoin (β‐hematin) formation in antiplasmodium chemical space. This 2‐dimensional landscape can be mined to unearth new chemotypes for antimalarial drug development.
Jessica L. Thibaud, Dirkie C. Myburgh, Rebecca D. Sandlin, Kim Y. Fong, Larnelle F. Garnie, Kathryn J. Wicht, David Kuter, David W. Wright, Timothy J. Egan, Katherine A. de Villiers   +9 more
wiley   +1 more source

Phenolic Profile and Bioactive Prospects of Wild Annona Species From Angola

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
ABSTRACT Annona species (Annonaceae family) are valued for their nutritional and medicinal importance, especially in traditional medicine. This study investigated the phenolic profiles of the Angolan Annona muricata, Annona squamosa, and Annona senegalensis leaves, stem barks, and seeds hydroethanolic, infusion, and decoction extracts, also evaluating ...
Josefa Rangel, Ângela Liberal, Tiane C. Finimundy, Tânia S. P. Pires, Pedro Cravo, Maria Conceição Silva, Gustavo Capatti Cassiano, Lillian Barros, Maria M. Romeiras, Ângela Fernandes   +9 more
wiley   +1 more source