Results 31 to 40 of about 537 (162)
Charge Transfer-oxy Radical Mechanism for Anti-cancer Agents [PDF]
, 1986 The proposal is advanced that anti-cancer drugs generally function by charge transfer resulting in formation of toxic oxy radicals which destroy the neoplasm.
Ames, James R. +5 more
core +1 more source
Extending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts. [PDF]
, 2014 BACKGROUND: An in silico mechanism-of-action analysis protocol was developed, comprising molecule bioactivity profiling, annotation of predicted targets with pathways and calculation of enrichment factors to highlight targets and pathways more likely to ...
Bender, Andreas +12 more
core +1 more source
5,8-Dimethyl-9H-carbazole Derivatives Blocking hTopo I Activity and Actin Dynamics [PDF]
, 2023 Over the years, carbazoles have been largely studied for their numerous biological properties, including antibacterial, antimalarial, antioxidant, antidiabetic, neuroprotective, anticancer, and many more. Some of them have gained great interest for their
Caruso, Anna +10 more
core +1 more source
Chemistry – A European Journal, Volume 31, Issue 72, December 23, 2025.The REG1CP‐derived RNA oligonucleotide SL15P adopts a parallel G‐quadruplex (rGQ) structure. In this study, we investigate the effect of several well‐characterized ligands, originally developed for DNA GQs, on the RNA counterpart, with the aim of evaluating their binding ability and specific binding modes.
Giuseppe Satta +2 more
wiley +1 more source
Carbazole Derivatives: A Promising Scenario for Breast Cancer Treatment [PDF]
, 2016 Chemotherapeutics used in cancer treatment may elicit pleiotropic effects interfering, for instance, directly on DNA metabolism or on endoplasmic organelles functions.
Cappello Ar +5 more
core +2 more sources
Molecular Oncology, Volume 19, Issue 11, Page 3035-3059, November 2025.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Induction of somatic mutation and recombination by four inhibitors of eukaryotic topoisomerases assayed in the wing spot test of Drosophila melanogaster [PDF]
, 2017 Four inhibitors of eukaryotic topoisomerases were investigated for genotoxic effects in the wing spot test of Drosophila melanogaster. As a somatic mutation and recombination test (SMART) this assay assesses mitotic recombination and mutational events of
Frei, Hansjörg, Würgler, Friedrich E.
core
Archiv der Pharmazie, Volume 358, Issue 7, July 2025.A mini‐library of cyclic triimidazo triazine derivatives functionalized with one, two, or three ethynyl‐N‐methyl‐pyridinium moieties was synthesized, characterized for the interaction with cancer‐related G‐quadruplexes, and tested in antiproliferative activity screenings on human cancer cells.
Chiara Platella +10 more
wiley +1 more source
Apoptosis: molecular mechanisms and pathogenicity [PDF]
Apoptosis triggered by exogenous and endogenous stimuli such as ultraviolet radiation, oxidative stress, and genotoxic chemicals is a crucial phenomenon within biological systems.
Rastogi, Rajesh P. +2 more
core +1 more source
Molecular Oncology, Volume 19, Issue 6, Page 1855-1875, June 2025.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source