Results 41 to 50 of about 537 (162)
Applied Organometallic Chemistry, Volume 39, Issue 6, June 2025.Two novel mononuclear Zn(II) (2a) and Mn(II) (2b) complexes and a hetero‐binuclear Zn(II)–Cu(II) (3a) complex have been reported. Their biological properties were examined and their computational studies were performed. Particularly, complexes 2b and 3 were observed to have strong interactions with DNA and showed effective antimicrobial ...
Ali Zengin +6 more
wiley +1 more source
An Expedient Flow Chemistry Approach to Substituted 1,4‐Dimethylcarbazoles
ChemistrySelect, Volume 10, Issue 13, April 4, 2025.The synthesis of substituted carbazoles, a privileged scaffolds in medicinal chemistry was translated to a robust flow chemistry methodology that enables continuous production of target materials. The reaction requires the use of simple indoles and 2,5‐hexanedione catalyzed under flow chemistry conditions through an in‐house constructed Omnifit ...
Jennifer R Baker +6 more
wiley +1 more source
The use of the palladium-catalyzed glycosylation for the synthesis of C- and O-linked glycosylated natural products [PDF]
, 2010 The carbohydrate portions of natural products play a crucial role in their pharmacological properties. These properties can vary from improved water solubility, improved membrane transport properties, improved tissue targeting, as well as improved target
Yu, Xiaomei
core +1 more source
A synthesis of 8,10-dimethoxyellipticine via a diphenylamine [PDF]
, 1995 8,10-Dimethoxyellipticine has been synthesised from readily available benzene derivatives via palladium acetate or photochemical cyclisation of intermediate diphenylamine derivatives.
Campos, Ana M. F. Oliveira +3 more
core +1 more source
Advanced Healthcare Materials, Volume 14, Issue 4, February 7, 2025.This review highlights the transformative potential of gold, silver, and iron oxide nanoparticles in cancer therapy. It explores their unique properties, recent advancements in synthesis and applications, and their roles in imaging and targeted therapies.
Priyanka Singh +6 more
wiley +1 more source
Food Science &Nutrition, Volume 13, Issue 1, January 2025.The phenolic profiling and in vitro bioactivities of five Asteraceae species were evaluated. Achillea millefolium and Arnica montana stand out as rich sources of phenolic compounds, which correlate with their significant antioxidant results. Chamaemelum nobile contained a high amount of flavonoids, which may be involved in its anti‐inflammatory effects.
Pascual Garcia‐Perez +9 more
wiley +1 more source
Medicinal Perspective of 2,4‐Thiazolidinediones Derivatives: An Insight into Recent Advancements
ChemistryOpen, Volume 13, Issue 11, November 2024.This article reviews recent advancements in the medicinal chemistry of 2,4‐thiazolidinedione derivatives, focusing on their synthesis, characterization, and therapeutic potential. Emphasis is placed on their roles in treating various diseases, highlighting their significance in medicinal chemistry and future perspectives. Abstract 2,4‐Thiazolidinedione
Sneha Gupta +4 more
wiley +1 more source
ChemMedChem, Volume 19, Issue 15, August 1, 2024.Twenty‐two phthalazine derivatives are designed, synthesized, and assessed against four human CA isoforms, showing notable activity against hCA IX and hCA I. Selective compounds exhibit a selectivity index up to 13.8. Docking analysis reveals active site interactions, and anticancer effects are tested on two breast cancer cell lines.
Andrea Angeli +10 more
wiley +1 more source
The FASEB Journal, Volume 38, Issue 1, 15 January 2024.Dynamin‐related protein 1 (Drp1) is a cytosolic protein that regulates mitochondrial fission. Heart ischemia/reperfusion (IR) injury results in Drp1 translocation to the mitochondrial outer mitochondrial membrane, mitochondrial swelling, and opening of the mitochondrial permeability transition pore (MPTP) associated with calcium overload, cytochrome C ...
Lin Piao +9 more
wiley +1 more source
Advances in Pharmacological and Pharmaceutical Sciences, Volume 2024, Issue 1, 2024.Background. The emergence of drug‐resistant parasites impedes disease management and eradication efforts. Hence, a reinvigorated attempt to search for potent lead compounds in the mangroves is imperative. Aim. This study evaluates in vitro antiplasmodial activity, antioxidant properties, and cytotoxicity of A. africana leaf alkaloidal extracts. Methods.
Mustapha A. Ahmed +9 more
wiley +1 more source