HPMA copolymer - aminoellipticine conjugates: mechanism of action. [PDF]
, 2002 Over the past two decades cancer chemotherapy has resulted in a small number of previously fatal cancers becoming curable. Many cancers, particularly the so-called solid tumours, do not respond well to conventional chemotherapy.
Keane, Richard
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Quadruplex Nucleic Acids as Novel Therapeutic Targets [PDF]
, 2016 Quadruplex-forming sequences are widely prevalent in human and other genomes, including bacterial ones. These sequences are over-represented in eukaryotic telomeres, promoters and 5' untranslated regions. They can form quadruplex structures, which may be
Neidle, S
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Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib modulate oxidation of an anticancer agent ellipticine catalyzed by cytochromes P450 in vitro [PDF]
, 2019 OBJECTIVES: Vandetanib¸ lenvatinib, and cabozantinib are tyrosine kinase inhibitors (TKIs) targeting VEGFR subtypes 1 and 2, EGFR and the RET-tyrosine kinase, thus considered as multiple TKIs.
Kolarik, Matus +6 more
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Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae) [PDF]
, 2018 Inhibition of the proliferation of human tumour cells and porcine non-tumour cells by the pygidial gland secretion released by adults of four ground beetle species was observed in this study.The sulphorhodamine B(SRB)assay was applied to establish the ...
Calhelha, Ricardo C. +6 more
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The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies:Studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN™) mice and pure enzymes [PDF]
, 2014 Ellipticine is a DNA-damaging agent acting as a prodrug whose pharmacological efficiencies and genotoxic side effects are dictated by activation with cytochrome P450 (CYP).
Arlt, Volker M +5 more
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Design, synthesis and evaluation of novel ellipticine derivatives and analogues as anti-cancer agents [PDF]
, 2011 This thesis describes work carried out on the synthesis of novel 5- and 11-substituted ellipticines and derivatives of the ellipticine analogues, isoellipticine and deazaellipticine, followed by investigation of their potential as anti-cancer agents ...
Miller, Charlotte M.
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3-Aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone, induces biotransformation enzymes in rat kidney and lung [PDF]
, 2009 3-Aminobenzanthrone (3-ABA) is the metabolite of the carcinogenic air pollutant 3-nitrobenzanthrone (3-NBA). 3-ABA was investigated for its ability to induce cytochrome P450 1A1 (CYP1A1) and NAD(P)H: quinone oxidoreductase (NQO1) in kidney and lung of ...
Arlt, Volker +10 more
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Palladium-catalyzed amination and cyclization to heteroannellated indoles and carbazoles [PDF]
, 2003 New ortho-bromodiarylamines in the benzo[b]thiophene series were prepared by palladium-catalyzed amination, either in the benzene or in the thiophene ring.
Chippendale +22 more
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Density Functional Molecular Study on the Full Conformational Space of the S-4-(2-Hydroxypropoxy)carbazol Fragment of Carvedilol (1-(9H−Carbazol-4-yloxy)-3- [2-(2-methoxyphenoxy)ethylamino]-2-propanol) in Vacuum and in Different Solvent Media [PDF]
, 2002 Density functional theory (DFT) conformational analysis was carried out on the potential energy hypersurface (PEHS) of the carbazole-containing molecular fragment, S-4-(2-hydroxypropoxy)-carbazol, of the chiral cardiovascular drug molecule carvedilol, (1-
Almeida David R. P. +6 more
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Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells [PDF]
, 2019 Although ellipticine (Elli) is an efficient anticancer agent, it exerts several adverse effects. One approach to decrease the adverse effects of drugs is their encapsulation inside a suitable nanocarrier, allowing targeted delivery to tumour tissue ...
Adam, Vojtěch +12 more
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