Results 101 to 110 of about 10,936 (259)

Non-linear MHD modelling of transients in tokamaks: a review of recent advances with the JOREK code

Nuclear Fusion
Transient magneto-hydrodynamic (MHD) events like edge localized modes (ELMs) or disruptions are a concern for magnetic confinement fusion power plants. Research with the MHD code JOREK towards understanding control of such instabilities is reviewed here ...
M. Hoelzl, G.T.A. Huijsmans, F.J. Artola, E. Nardon, M. Becoulet, N. Schwarz, A. Cathey, S.J.P. Pamela, K. Aleynikova, F. Antlitz, V. Bandaru, H. Bergström, A. Bhole, T. Bogaarts, D. Bonfiglio, F. Cipolletta, T. Driessen, L. Edes, S. Futatani, G. Hao, F. Hindenlang, I. Holod, D. Hu, S. Hu, N. Isernia, H. Isliker, S.K. Kim, M. Kong, S. Korving, L. Kos, I. Krebs, S.J. Lee, Y.C. Liang, Z. Liang, S.J. Liu, Z.X. Lu, L. Meier, L. Messfeldt, V. Mitterauer, N. Nikulsin, B. Nkonga, R. Ramasamy, J. Reinking, C. Rogge, G. Rubinacci, K. Särkimäki, T. Smits, C. Sommariva, R. Sparago, K. Strien, M. Szucs, W. Tang, J. van Tongeren, F. Vannini, S. Ventre, F. Villone, C. Wang, L. Wang, F. Wieschollek, F. Wouters, J. Zielinski, H. Zhang   +61 more
doaj   +1 more source

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis

Advanced Science, EarlyView.
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou, Wan Fu, Shizuo Liu, Zili Zhang, Hanyan Luo, Qing Zhong   +5 more
wiley   +1 more source

Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications

Advanced Science, EarlyView.
Classical transfection and transduction are inefficient, particularly with confluent cells and organoids, and lack cell type‐specific programmability. This study presents calcium shock (CaSh), a method that dramatically improves particle delivery into single cells, colonies, and organoids.
Nicole Vo, Lorena de Oñate, Maximillian Frank, Xian Hu, Sophie M. Blackburn, Dana V. Foss, Jasmine Villegas, Kunica Asija, Dirk Hockemeyer, Hongxia Fu, Raymond J. Monnat, Ross C. Wilson, Benjamin S. Freedman   +12 more
wiley   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Mesoscale Recovery of Microglial and Neuronal Dynamics After Craniotomy Across Wide Cortex in Transgenic Mice

Advanced Science, EarlyView.
This study employs longitudinal fluorescence imaging in transgenic mice to map post‐craniotomy cortical recovery. We identify distinct neuroimmune recovery phases: microglial structural inflammation peaks at ∼10 days, neuronal structural intensity peaks at ∼14 days and correlates with microglial activity, and functional network modularity is most ...
Guihua Xiao, Zhilei Wang, Pengchang Zheng, Jingyu Xie, Yangzhen Wang, Yun Chen, Zilin Wang, Ao Li, Minghuan Wang, Quanbo Ji, Can Gao, Di Yao, Lingbo Li, Jiangbei Cao   +13 more
wiley   +1 more source

First experimental observation of QH-mode with EHOs on the HL-3 tokamak

Nuclear Fusion
The quiescent H-mode (QH-mode), free of edge localized mode (ELM), is a promising operational regime for future fusion devices due to its low collisionality and high confinement performance.
Y. Zhang, Y. Zhou, N. Wu, Y.R. Zhu, W. Chen, Z.B. Guo, G.Q. Dong, R. Ke, A.S. Liang, S.Q. Wang, M. Jiang, Z.Y. Li, Y.F. Wang, X. Feng, Y.Q. Shen, S.B. Gong, Z.Y. Yin, X. Yu, S.S. Yang, S. Xu, Z. Wang, L.W. Hu, T.F. Sun, D. Li, J.Z. Zhang, Y.H. Chen, G.Z. Hao, G.L. Xiao, B. Li, W.L. Zhong   +29 more
doaj   +1 more source

Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging

Advanced Science, EarlyView.
Cell death is important in both the development and treatment of cancer. In this study, it is demonstrated for the first time that a specific measurement of the transmembrane water exchange rate using magnetic resonance imaging can be used as an early marker of cell death in mammalian cells, in animals and in human patients. Abstract Cell death plays a
Athanasia Kaika, Luca Nagel, Ulrike Höckendorf, Bangwen Xie, Geoffrey J. Topping, Mathias Schillmaier, Irina Beer, Frits H. A. van Heijster, Julian Rauch, Tristan A. Kuder, Sandra Sühnel, Bernd Erber, Christian Lohrmann, Simone Ballke, Thomas Metzler, Katja Steiger, Philipp J. Jost, Natalia P. Ivleva, Philipp Paprottka, Jonathan Nadjiri, Kevin M. Brindle, Wolfgang A. Weber, Franz Schilling   +22 more
wiley   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Observation of a stationary double transport barrier in KSTAR

Nuclear Fusion
We have observed a stationary high confinement regime with a double transport barrier (DTB), including both internal and edge transport barriers (ITB and ETB) but without edge-localized modes (ELMs), in KSTAR.
M.W. Lee, S.-H. Hahn, D. Kim, J. Kang, W.H. Ko, J. Jang, W. Lee, C. Sung   +7 more
doaj   +1 more source

cDC1 Subtype‐Specific In Vivo Targeting of Liposomes

Advanced Science, EarlyView.
Dendritic cells, particularly the cDC1 subtype, offer a promising target for drug delivery via liposomes due to their pivotal role in immune regulation, allowing for amplified therapeutic responses. Herein, we show an integration of physicochemical characterization and cell experiments to achieve effective in vivo cDC1 targeting through anti‐CLEC9A ...
Maximilian Schaaf, Michael Fichter, Lin Jian, Felicia Schön, Carina Jung, Paul Schneider, Kai Speth, Ana Mateos‐Maroto, Volker Mailänder, Kaloian Koynov, Svenja Morsbach, Katharina Landfester   +11 more
wiley   +1 more source