Results 21 to 30 of about 17,052 (265)

Progress and issues in understanding the physics of ELM dynamics, ELM mitigation, and ELM control

Journal of Physics: Conference Series, 2008
Recent experimental progress in understanding the dynamics of type I ELM, small/no ELM regimes to achieve ELM mitigation and active ELM controls is reviewed. As for the type I ELM dynamics, the smaller growth rate of the ELM precursor relative to the Alfven frequency, the importance of ELM filaments to evaluate the ELM heat load, the evolution of ...
openaire   +1 more source

HPV vaccination: Pilot study assessing characteristics of high and low performing primary care offices

Preventive Medicine Reports, 2018
This pilot study was undertaken to identify characteristics and approaches (e.g., social, behavioral, and/or systems factors) which differentiate primary care medical offices achieving higher rates of HPV vaccination.Eligible primary care practice sites ...
Allison Lollier, Elisa M. Rodriguez, Frances G. Saad-Harfouche, Christy A. Widman, Martin C. Mahoney   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Data-Driven Model-Free Adaptive Control Based on Error Minimized Regularized Online Sequential Extreme Learning Machine

Energies, 2019
Model-free adaptive control (MFAC) builds a virtual equivalent dynamic linearized model by using a dynamic linearization technique. The virtual equivalent dynamic linearized model contains some time-varying parameters, time-varying parameters usually ...
Xiaofei Zhang, Hongbin Ma
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Experimental validation of an improved adaptive predefined time SMC for servo nonlinear system under multiple uncertainties [PDF]

AIP Advances
Accurate position tracking in seeker servos, robotics, and numerous industrial dynamic systems is a complex task, especially when there are variations in the parameters or any form of external disturbances.
Saleem Riaz
doaj   +1 more source

Thermal error modeling of electrical spindle based on optimized ELM with marine predator algorithm

Case Studies in Thermal Engineering, 2022
High-speed electric spindle is an important part of computer numerical control (CNC) machining equipment, and the thermal displacement generated by the electric spindle during operation affects the electric spindle machining stability and machining ...
Zhaolong Li, Baodong Wang, Bo Zhu, Qinghai Wang, Wenming Zhu   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Application of electrochemical sensor modified by SBA-15 /Fe3O4/polyaniline nanocomposite for determination of tyrosine in milk samples

Sensing and Bio-Sensing Research, 2023
In this study, a selective SBA-15 /Fe3O4/Polyaniline /Chitosan nanocomposite was successfully electrodeposited on Screen- Printed Carbon Electrode (SPCE) and used for L-Tyrosine (Tyr) detection.Biological diagnostic probes such as artificial receptors ...
Faeze Khanmohammadi, BiBi Marziyeh Razavizadeh, Ebrahim Fooladi   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source