Results 51 to 60 of about 1,967 (171)
IKAP/Elp1 involvement in cytoskeleton regulation and implication for familial dysautonomia [PDF]
Human Molecular Genetics, 2011 Deficiency in the IKAP/Elp1 protein leads to the recessive sensory autosomal congenital neuropathy which is called familial dysautonomia (FD). This protein was originally identified as a role player in transcriptional elongation being a subunit of the RNAPII transcriptional Elongator multi-protein complex.
David, Cheishvili +6 more
openaire +2 more sources
Molecules, 2022 The anticancer agent doxorubicin(dox) has been widely used in the treatment of a variety of hematological malignancies and solid tumors. Despite doxorubicin’s efficiency in killing tumor cells, severe damage to healthy tissues, along with cardiotoxicity,
Sonja Dragojevic +3 more
doaj +1 more source
A neuron autonomous role for the familial dysautonomia geneELP1in sympathetic and sensory target tissue innervation [PDF]
Development, 2014 Familial dysautonomia (FD) is characterized by severe and progressive sympathetic and sensory neuron loss caused by a highly conserved germline point mutation of the human ELP1/IKBKAP gene. Elp1 is a subunit of the hetero-hexameric transcriptional elongator complex, but how it functions in disease-vulnerable neurons is unknown.
Marisa Z. Jackson +3 more
openalex +4 more sources
Research progress of the Elongator complex in plant
Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2023 The Elongator complex consists of six subunits (ELP1-ELP6), where ELP1-ELP3 forms the core subcomplex and ELP4-ELP6 forms the auxiliary subcomplex. Deletion of any of the six subunits results in an almost identical phenotype, suggesting that all six ...
Ji XIANGZHUO +4 more
doaj +1 more source
A conserved and essential basic region mediates tRNA binding to the Elp1 subunit of the Saccharomyces cerevisiae Elongator complex [PDF]
, 2014 Elongator is a conserved, multi-protein complex discovered in Saccharomyces cerevisiae, loss of which confers a range of pleiotropic phenotypes. Elongator in higher eukaryotes is required for normal growth and development and a mutation in the largest ...
Amberg D.C. +5 more
core +4 more sources
Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models
Nature Communications, 2022 Sympathetic neurons are affected in familial dysautonomia, a rare disease associated with a mutation in ELP1, but the mechanisms are not fully understood.
Hsueh-Fu Wu +8 more
doaj +1 more source
Graded polynomial identities and central polynomials of matrices over an infinite integral domain [PDF]
, 2014 Let $K$ be an infinite integral domain and $M_{n}(K)$ be the algebra of all $n\times n$ matrices over $K$. This paper aims for the following goals: Find a basis for the graded identities for elementary grading in $M_{n}(K)$ when the neutral component ...
Fonseca, Luís Felipe Gonçalves
core +1 more source
European Journal of Medicinal ChemistryFamilial dysautonomia is a debilitating congenital neurodegenerative disorder with no causative therapy. It is caused by a homozygous mutation in ELP1 gene, resulting in the production of the transcript lacking exon 20. The compounds studied as potential treatments include the clinical candidate kinetin, a plant hormone from the cytokinin family.
Barbara Maková +15 more
openalex +4 more sources
Elongator and its epigenetic role in plant development and responses to abiotic and biotic stresses [PDF]
, 2015 Elongator, a six-subunit protein complex, was initially isolated as an interactor of hyperphosphorylated RNA polymerase II in yeast, and was subsequently identified in animals and plants.
Yezhang Ding, Zhonglin Mou
core +2 more sources