Results 21 to 30 of about 1,744 (195)

DESCRIPCIÓN PRECISA DE LAS TRANSACCIONES ENTRE PARTES VINCULADAS, DESCONOCIMIENTO O SUSTITUCIÓN DE LAS MISMAS Y SU RELACIÓN CON LAS CLÁUSULAS ANTIABUSO GENERALES [PDF]

open access: yesCrónica Tributaria, 2017
El presente artículo se centra en analizar la relación entre, por un lado, el desconocimiento y la recaracterización de operaciones entre partes vinculadas en aplicación del principio de libre concurrencia y, por el otro, las cláusulas antiabuso ...
José Antonio García Bañuelos   +1 more
doaj  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

EL PROYECTO BEPS DE LA OCDE/G20: RESULTADOS FINALES [PDF]

open access: yesCrónica Tributaria, 2016
La extremadamente agresiva planificación fiscal llevada a cabo por determinadas multinacionales a nivel internacional ha obligado a los países a buscar soluciones coordinadas para hacer frente a este problema común.
Mar Barreno   +8 more
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

REFLEXIONES SOBRE EL MODELO CHILENO DE POLÍTICA FISCAL INTERNACIONAL (*) [PDF]

open access: yesCrónica Tributaria, 2013
El artículo contiene un análisis de varios problemas denominados errores no forzados de la política fiscal internacional seguida por la Administración Fiscal de Chile.
Cristián Gárate
doaj  

Procedimiento para aplicar la cláusula general antiabuso

open access: yesRevista de Derecho Fiscal, 2017
Por décadas Colombia ha tenido una gran preocupación por el riesgo de la elusión fiscal, por esta razón el Congreso colombiano introdujo en su estatuto fiscal la Norma General Antielusión, mediante la Ley 1607 de 2012.
Pablo Mauricio Sarmiento Mancipe
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

CLÁUSULA ANTIABUSO VERSUS FRAUDE DE LEY: ¿DOS CONCEPTOS SEMEJANTES EN LA LEY GENERAL TRIBUTARIA? [PDF]

open access: yesCrónica Tributaria, 2007
El presente trabajo pretende analizar el alcance y la naturaleza que ofrece la figura de la «cláusula antiabuso» o «conflicto en la aplicación de la norma» en la Ley 58/2003, de 17 de diciembre, General Tributaria, a través de un estudio comparativo de ...
Juan Calvo Vérgez
doaj  

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

open access: yesFEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang   +7 more
wiley   +1 more source

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