Results 51 to 60 of about 3,190 (231)

Control Tributario para Evitar la Elusion de Impuestos de los Pequeños y Medianos Negocios de Portoviejo

Ciencia Latina Revista Científica Multidisciplinar
El objetivo principal de la investigación es examinar de qué manera el control tributario puede además de detectar y sancionar la elusión de impuestos, ofrecer respaldo y guía a los pequeños y medianos negocios para asegurar su cumplimiento fiscal, para ...
Jenny Margoth Mendoza Orellana, Laura Margarita Rosales Delgado   +1 more
semanticscholar   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Procedimiento para aplicar la cláusula general antiabuso

Revista de Derecho Fiscal, 2017
Por décadas Colombia ha tenido una gran preocupación por el riesgo de la elusión fiscal, por esta razón el Congreso colombiano introdujo en su estatuto fiscal la Norma General Antielusión, mediante la Ley 1607 de 2012.
Pablo Mauricio Sarmiento Mancipe
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

El consenso a la imposición en la fiscalidad global

Thēmis, 2019
El ámbito económico internacional de las naciones ha sufrido cambios acelerados desde el final del siglo XX hasta nuestros días. El aislacionismo económico característico de siglos anteriores al nuestro ha quedado en el pasado y, así, las instituciones ...
Francesco Farri
doaj  

CLÁUSULA ANTIABUSO VERSUS FRAUDE DE LEY: ¿DOS CONCEPTOS SEMEJANTES EN LA LEY GENERAL TRIBUTARIA? [PDF]

Crónica Tributaria, 2007
El presente trabajo pretende analizar el alcance y la naturaleza que ofrece la figura de la «cláusula antiabuso» o «conflicto en la aplicación de la norma» en la Ley 58/2003, de 17 de diciembre, General Tributaria, a través de un estudio comparativo de ...
Juan Calvo Vérgez
doaj  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Liquid Phase Transmission Electron Microscopy: A Window into the Early Stages of Complex Material Formation

Advanced Functional Materials, EarlyView.
Liquid‐phase transmission electron microscopy enables direct observation of nucleation and growth processes in solution. This review is dedicated to the remembrance of Helmut Cölfen and highlights recent studies on complex materials—oxides, biominerals, organic–inorganic crystals—which were central to his research activity. It summarizes key milestones,
Charles Sidhoum, Vinavadini Ramnarain, Nathaly Ortiz Peña, Dris Ihiawakrim, Clément Sanchez, Ovidiu Ersen   +5 more
wiley   +1 more source