A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Purification and analytical characterization of an anti- CD4 monoclonal antibody for human therapy [PDF]
, 1994 A purification process for the monclonal anti-CD4 antibody MAX.16H5 was developed on an analytical scale using (NH&SO, precipitation, anion-exchange chromatography on MonoQ or Q-Sepharose, hydrophobic interaction chromatography on phenyl- Sepharose and ...
Emmrich, F. +8 more
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Comparison of polymethylmethacrylate (PMMA), native calcium sulfate, and high porous calcium sulfate beads as gentamicin carriers and osteoblast attachment [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2013 Calcium sulfate, a bioresorbable material, has been used as a bone substitute material and antibiotic vehicle. The increasing porosity of calcium sulfate beads might improve drug delivery capacity as well as enhance the antibiotic elution property.
Chaiyakorn Thitiyanaporn +2 more
doaj
Drug-eluting stent thrombosis [PDF]
Therapeutic Advances in Cardiovascular Disease, 2009 Stent thrombosis is a rare complication following stent implantation; if it occurs, however, it is associated with a high morbidity and mortality. Despite reduced rates of restenosis, drug-eluting stents (DES) have not reduced the incidence of stent thrombosis as compared with bare-metal stents (BMS).
Stähli, B E, Camici, G G, Tanner, F C
openaire +3 more sources
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
Recovery of viral RNA and infectious foot-and-mouth disease virus from positive lateral-flow devices [PDF]
, 2014 Foot-and-mouth disease Virus (FMDV) is an economically important, highly contagious picornavirus that affects both wild and domesticated cloven hooved animals. In developing countries, the effective laboratory diagnosis of foot-and-mouth disease (FMD) is
Armson, Bryony +10 more
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The Kounis syndrome in everolimus‐eluting stents and paclitaxel‐eluting stents
Catheterization and Cardiovascular Interventions, 2010 Catheter Cardiovasc ...
Kounis, N. G. +2 more
openaire +3 more sources
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Nitric acid-organic mixtures surveyed for use in separation by anion exchange methods [PDF]
, 1968 Column elution-spectrographic analysis technique compares certain solvents directly to the methanol system, using inert rare earths instead of actinides. Distribution ratios for americium between 90 percent solvent, 10 percent 5 M nitric acid and Dowex 1
Bloomquist, C. A. A. +2 more
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Chemical analysis of soluble fractions from normal and autolysed rabbit liver by column chromatography [PDF]
, 1966 Chromatography on Sephadex G-200 was performed with the soluble fraction of homogenated rabbit liver, which was extracted with 0.1 M phosphate buffer containing 0.1 M NaCl.
Aizawa, Tadashi +4 more
core +1 more source