Results 31 to 40 of about 6,978 (279)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Contribution of Emanationist Philosophy to the Development of Environmental Conservation
An-Nida'The global ecological crisis demonstrates that contemporary ethical frameworks have been insufficient in mitigating the accelerating rate of environmental degradation.
Rifqah Najwa Azizah +3 more
doaj +1 more source
No Ontological Leaps: A Primer on Scientific Materialism [PDF]
Integral Review, 2011 When the issue is intelligence in nature, arguments about whether science supports neo-Darwinian theory or intelligent design miss the point. The details of evolution or the structure of the brain are irrelevant because biology and neuroscience have ...
Christian de Quincey
doaj
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Measurement of radon in soils of Lima City - Peru during the period 2016-2017
Earth Sciences Research Journal, 2019 Lima City is situated on alluvial fan deposits of rivers flowing through geological formations that contain different levels of uranium. In this paper, a study is made on the average spatial and temporal behavior of radon gas in soils of Lima City. Radon
Luís Vilcapoma Lázaro +6 more
doaj +1 more source
Symbolic Emanations of God’s Great Title in Monotheism figures in the Islamic Art and Architecture Works [PDF]
نگره, 2017 The main issue is to study the quality of semantic implications of God’s great title in Islamic art and architecture works. The purpose is to gain the secret behind immortality of symbolic language of forms, figures, patterns, and structures of Islamic ...
fatemeh akbari
doaj +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source