Results 81 to 90 of about 30,481 (286)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

“Emanating from Mastaba”

Annals of Indian Academy of Neurology, 2021
Just when the caterpillar thought it has been wound up into a mastaba, it became a butterfly.
openaire   +3 more sources

Measurement of radon concentrations at Super-Kamiokande

, 1999
Radioactivity from radon is a major background for observing solar neutrinos at Super-Kamiokande. In this paper, we describe the measurement of radon concentrations at Super-Kamiokande, the method of radon reduction, and the radon monitoring system.
A Habig, A Hasegawa, A Kibayashi, A Okada, A Sakai, A Suzuki, A.L Stachyra, A.T Suzuki, B Viren, B.K Kim, C Mauger, C McGrew, C Saji, C Yanagisawa, C.K Jung, C.W Walter, D Casper, D Kielczewska, D Takemori, E Blaufuss, E Kearns, E Sharkey, F Tsushima, Fukuda, G.W Sullivan, H Fujiyasu, H Ishino, H Ogawa, H Okazawa, H Takeuchi, H.W Sobel, J Hill, J Kameda, J Kanzaki, J Shirai, J.A Goodman, J.G Learned, J.L Stone, J.S George, K Higuchi, K Inoue, K Ishihara, K Kaneyuki, K Kobayashi, K Martens, K Miyano, K Nakamura, K Nishijima, K Nishikawa, K Okumura, K Scholberg, K.K Young, K.S Ganezer, L.L Wai, L.R Price, L.R Sulak, M Earl, M Etoh, M Goldhaber, M Kirisawa, M Koga, M Kohama, M Koike, M Koshiba, M Miura, M Nakahata, M Nemoto, M Sakuda, M Shiozawa, M Smy, M Takahashi, M Takahata, M Takita, M Yoshida, M.D Messier, M.L Chen, M.R Vagins, N Sakurai, Nemoto, O Sasaki, R Sanford, R Svoboda, R.J Wilkes, R.W Ellsworth, S Echigo, S Hatakeyama, S Inaba, S Kasuga, S Matsuno, S Mine, S Nakayama, S Tasaka, S Yamada, S.B Kim, T Barszczak, T Futagami, T Hasegawa, T Hayakawa, T Ishii, T Iwamoto, T Kajita, T Kobayashi, T Maruyama, T Yamaguchi, T.J Haines, Takeuchi, Tasaka, V.J Stenger, W Doki, W Gajewski, W.E Keig, W.R Kropp, Y Fukuda, Y Hatakeyama, Y Hayato, Y Itow, Y Kanaya, Y Kobayashi, Y Koshio, Y Nagashima, Y Obayashi, Y Oyama, Y Suzuki, Y Takeuchi, Y Totsuka, Y Watanabe   +125 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

ABDURREZZÂK EL-LÂHÎCÎ’DE SUDÛRUN İMKÂNI BAĞLAMINDA SOYUT CEVHERLER

Fırat Üniversitesi İlahiyat Fakültesi Dergisi, 2016
Felsefe ve kelam arasında cereyan eden önemli tartışmalardan biri de hiç şüphesiz “sudûr teorisi”dir. Filozoflar söz konusu bu teorinin imkân ve tutarlılığını mücerred cevherler/akıl ve nefs” kavramı üzerinden izah etmeye çalışmışlardır.
Ahmet Pirinç
doaj  

Exhalation Rate Study of Thoron in Some Building Materials of the Iberian Peninsula

Proceedings, 2018
Thoron isotope has been growing in importance in the last years because, despite of its short half-life, can also contribute in the development of lung cancer.
Samuel Frutos-Puerto, Eduardo Pinilla-Gil, Conrado Miró, Eva Andrade, Mario Reis, María José Madruga   +5 more
doaj   +1 more source