Results 61 to 70 of about 542,476 (304)

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Surgical interventions for the early management of Bell's palsy [PDF]

, 2011
Background: Bell's palsy is an acute paralysis of one side of the face of unknown aetiology. Bell's palsy should only be used as a diagnosis in the absence of all other pathology.
Adour, Adour, Adour, Antoni, Aoyagi, Ballance, Brown, DerSimonian, Engstrom, Fisch, Fisch, Fisch, Friedman, Gantz, Giancarlo, Lockhart, May, May, May, McCormick, McNeill, Mechelse, Morgenlander, Peitersen, Salinas, Sillman, Spiegelhalter, Stjernquist-Desatnik, Sullivan, Theil, Yanagihara   +30 more
core   +3 more sources

Clinical Significance of Therapeutic Drug Level Monitoring for Mycophenolate in Patients With Extrarenal Systemic Lupus Erythematosus—A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective Clinical response to mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug level monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with systemic lupus erythematosus (SLE ...
Zahraa Qamhieh, Dalia Sriwi, Callie Saric, Tripti Singh, Christie M. Bartels, Shivani Garg   +5 more
wiley   +1 more source

Developing optimal search strategies for detecting clinically sound and relevant causation studies in EMBASE

BMC Medical Informatics and Decision Making, 2005
Background Evaluating the existence and strength of an association between a putative cause and adverse clinical outcome is complex and best done by assessing all available evidence.
Kastner Monika, Haynes R Brian, Wilczynski Nancy L   +2 more
doaj   +1 more source

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

Journal Selection Criteria and Benefits in Embase and Scopus [PDF]

Taṣvīr-i salāmat, 2013
Growth of scientific products is one of the important reasons for indexing journals  in scientific databases. Increasing Article  Visibility and Audience Access one the adventages of indexing.
doaj  

Views of healthcare professionals to linkage of routinely collected healthcare data : a systematic review [PDF]

, 2013
Peer reviewedPublisher ...
Bond, C, Francis, J, Haughney, J, Helms, P J, Hopf, Y M   +4 more
core   +2 more sources

Extralevator Abdominoperineal Excision Improves Overall Survival Compared to Standard Abdominoperineal Excision: A Systematic Review and Meta‐Analysis

Annals of Gastroenterological Surgery, EarlyView.
This systematic review and meta‐analysis of 38 studies, encompassing over 5000 patients, compared extralevator abdominoperineal excision (ELAPE) with standard abdominoperineal excision (APE) in patients with advanced low rectal cancer. ELAPE was associated with significantly improved overall and disease‐free survival, reduced intraoperative perforation
Sarolta Beáta Kávási, Diana‐Elena Floria, Anett Rancz, Dániel Sándor Veres, Nándor Faluhelyi, Pál Miheller, Péter Hegyi, Szabolcs Ábrahám   +7 more
wiley   +1 more source

Strategies to optimize MEDLINE and EMBASE search strategies for anesthesiology systematic reviews. An experimental study

São Paulo Medical Journal, 2018
BACKGROUND: A high-quality electronic search is essential for ensuring accuracy and comprehensiveness among the records retrieved when conducting systematic reviews. Therefore, we aimed to identify the most efficient method for searching in both MEDLINE
Enilze de Souza Nogueira Volpato, Marluci Betini, Maria Eduarda Puga, Arnav Agarwal, Antônio José Maria Cataneo, Luciane Dias de Oliveira, Rodrigo Bazan, Leandro Gobbo Braz, José Eduardo Guimarães Pereira, Regina El Dib   +9 more
doaj   +1 more source

Robotic Versus Laparoscopic Anatomic Liver Resection: Comparison of Perioperative Outcomes—A Systematic Review and Meta‐Analysis

Annals of Gastroenterological Surgery, EarlyView.
Minimally invasive anatomic liver resection (AR) including major hepatectomy and liver parenchyma‐sparing AR is technically complex and demanding. This systematic review with meta‐analysis including 15 studies comparing 2042 robotic AR and 2129 laparoscopic AR patients demonstrated largely comparable perioperative outcomes and partly better outcomes ...
Yutaro Kato, Atsushi Sugioka, Hiroyuki Kato, Akihiko Horiguchi   +3 more
wiley   +1 more source