Results 51 to 60 of about 55,940 (225)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

“I spy, with my little sensor”: fair data handling practices for robots between privacy, copyright and security

Connection Science, 2017
The paper suggests an amendment to Principle 4 of ethical robot design, and a demand for “transparency by design”. It argues that while misleading vulnerable users as to the nature of a robot is a serious ethical issue, other forms of intentionally ...
Burkhard Schafer, Lilian Edwards
doaj   +1 more source

Hiding data in audio files: A smoothing-based approach to improve the quality of the stego audio

Heliyon, 2020
In this digital era, transmitting data through a computer network has become common. Moreover, some applications have also been developed to do it. Nevertheless, users may not be aware of the security aspect of this data transmission, which can lead to ...
Tohari Ahmad, Muhammad Hanif Amrizal, Waskitho Wibisono, Royyana Muslim Ijtihadie   +3 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

An Approach to Potentially Increasing Adoption of an Artificial Intelligence–Enabled Electronic Medical Record Encounter in Canadian Primary Care: Protocol for a User-Centered Design

JMIR Research Protocols
BackgroundPrimary care physicians are at the forefront of the clinical process that can lead to diagnosis, referral, and treatment.
Krizia Mae Francisco, Catherine M Burns
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

ExEmPLAR (Extracting, Exploring, and Embedding Pathways Leading to Actionable Research): a user-friendly interface for knowledge graph mining

Bioinformatics
Abstract Summary Knowledge graphs are being increasingly used in biomedical research to link large amounts of heterogenous data and facilitate reasoning across diverse knowledge sources. Wider adoption and exploration of knowledge graphs in the biomedical research community is limited by requirements ...
Tucker, Nyssa N, Muratov, Eugene N, Alves, Erick T M, Korn, Daniel R, Beasley, Jon-Michael T, Tropsha, Alexander, Bizon, Chris   +6 more
openaire   +2 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Artifacts in photoacoustic imaging: Origins and mitigations

Photoacoustics
Photoacoustic imaging (PAI) is rapidly moving from the laboratory to the clinic, increasing the need to understand confounders which might adversely affect patient care.
Max T. Rietberg, Janek Gröhl, Thomas R. Else, Sarah E. Bohndiek, Srirang Manohar, Benjamin T. Cox   +5 more
doaj   +1 more source