Results 91 to 100 of about 606,496 (268)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Entropy-Regulated Job-Shop Scheduling: A Bottom–Up Artificial Bee Colony Algorithm for Semiconductor Manufacturing

IEEE Access
This paper addresses the Job-Shop Scheduling Problem in dynamic semiconductor manufacturing environments by proposing a decentralized, bottom-up Artificial Bee Colony (ABC) scheduling algorithm.
Elnaz Khatmi, Khalil Al-Rahman Youssefi, Wilfried Elmenreich   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

LUT-Based Convolutional Tsetlin Machine Accelerator With Dynamic Clause Scaling for Resources-Constrained FPGAs

IEEE Journal on Exploratory Solid-State Computational Devices and Circuits
The rapid growth of machine learning (ML) workloads, particularly in computer vision applications, has significantly increased computational and energy demands in modern electronic systems, motivating the use of hardware accelerators to offload ...
Rashed Al Amin, Roman Obermaisser
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

4DO-DETR for otitis media detection

Scientific Reports
Otitis media (OM) and its complications can cause immense suffering for patients. However, due to the limited number of experts and their knowledge base, human specialists can only handle a limited number of CT images.
Xinyue Zhao, Haowen Zhang, Dong Liu, Guanxiong Lei   +3 more
doaj   +1 more source

A Review of Artificial Intelligence in Embedded Systems. [PDF]

Micromachines (Basel), 2023
Zhang Z, Li J.
europepmc   +1 more source

Embedding asymptotically expansive systems

Monatshefte für Mathematik, 2017
We prove a Krieger like embedding theorem for asymptotically expansive systems with the small boundary property. We show that such a system $(X; T)$ embeds in the $K$-full shift with $h_{top}(T) < \log K $ and $\sharp Per_n(X; T) \leq \sharp Per_n(\{1,...,K\}^{\mathbb{Z}};σ)$ for any integer $n$.
openaire   +4 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source