Results 131 to 140 of about 555,379 (343)

FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production

open access: yesFEBS Open Bio, EarlyView.
FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley   +1 more source

Creep Characterization of Inconel 718 Lattice Metamaterials Manufactured by Laser Powder Bed Fusion

open access: yesAdvanced Engineering Materials, EarlyView., 2023
Herein, the creep characteristics of additively manufactured Inconel 718 metamaterials are investigated. The creep behavior of metamaterials and the effects of microstructural defects are assessed, and the microstructure defects are accurately captured using Kachanov's creep damage model.
Akash Singh Bhuwal   +5 more
wiley   +1 more source

Universes and simulations: Civilizational development in nested embedding

open access: yesFoundations of Computing and Decision Sciences, 2018
The rapid development of technology has allowed computer simulations to become routinely used in an increasing number of fields of science. These simulations become more and more realistic, and their energetic efficiency grows due to progress in computer
Komosinski Maciej
doaj   +1 more source

Embedding graphs into embedded graphs [PDF]

open access: yesarXiv, 2016
A (possibly denerate) drawing of a graph $G$ in the plane is approximable by an embedding if it can be turned into an embedding by an arbitrarily small perturbation. We show that testing, whether a straight-line drawing of a planar graph $G$ in the plane is approximable by an embedding, can be carried out in polynomial time, if a desired embedding of ...
arxiv  

Proximities and Embedding Effects [PDF]

open access: yesEuropean Planning Studies, 2008
Clusters are supposed to enhance exchanges among firms or between firms and research institutions. This is termed “proximities effects” in this paper. There are many theories explaining proximities effects, but most of them lack a clear distinction between levels of action (individuals, social networks, firms, markets, etc.).
openaire   +5 more sources

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

open access: yesFEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy   +14 more
wiley   +1 more source

A Variational Beam Model for Failure of Cellular and Truss‐Based Architected Materials

open access: yesAdvanced Engineering Materials, EarlyView., 2023
Herein, a versatile and efficient beam modeling framework is developed to predict the nonlinear response and failure of cellular, truss‐based, and woven architected materials. It enables the exploration of their design space and the optimization of their mechanical behavior in the nonlinear regime. A variational formulation of a beam model is presented
Konstantinos Karapiperis   +3 more
wiley   +1 more source

An Information Gradient Approach to Optimizing Traffic Sensor Placement in Statewide Networks

open access: yesInformation
Traffic sensors are vital to the development and operation of Intelligent Transportation Systems, providing essential data for traffic monitoring, management, and transportation infrastructure planning. However, optimizing the placement of these sensors,
Yunxiang Yang, Hao Zhen, Jidong J. Yang
doaj   +1 more source

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