Results 131 to 140 of about 1,302,695 (334)

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

open access: yesMolecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi   +12 more
wiley   +1 more source

Quadratic embeddings

open access: yes, 2012
The quadratic Veronese embedding $ $ maps the point set $P$ of $\PG{n,F)$ into the point set of $PG({n+2 \choose 2}-1, F$ ($F$ a commutative field) and has the following well-known property: If $M\subset P$, then the intersection of all quadrics containing $M$ is the inverse image of the linear closure of $M^ $.
Havlicek, Hans, Zanella, Corrado
openaire   +3 more sources

An Automatic Framework Recognizing the Relationships of Cultural Heritage

open access: yesIEEE Access
The field of cultural heritage has developed over a long period, accumulating a wealth of research findings. Researchers are now focusing on systematic relationships and taxonomic studies of heritage, exploring the underlying cultural information ...
Zizhan Zhang, Zijun Zhou, Yingchun Cao
doaj   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

open access: yesMolecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh   +5 more
wiley   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

open access: yesMolecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha   +10 more
wiley   +1 more source

Natural Intelligence in Search of Ways to Apply Artificial One (Results of the Scientific and Practical Conference “The Use of Artificial Intelligence in Library and Information Activities”)

open access: yesБиблиосфера
The article is an analytical review of reports and presentations made at the scientific conference “Application of Artificial Intelligence in Library and Information Activities” and held by INION RAS on May 29, 2024.
V. K. Stepanov
doaj   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

open access: yesMolecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik   +4 more
wiley   +1 more source

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