Results 51 to 60 of about 525,882 (299)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Proceedings of the American Mathematical Society, 1973 In this paper we generalize the notion of exact functor to an arbitrary category and show that every small category has a full embedding into a category of all set-valued functors on some small category. The notion of exact is such that this result generalizes the author’s exact embedding of regular categories and, indeed, Mitchell’s embedding of ...
openaire +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Using Hybrid HMM/DNN Embedding Extractor Models in Computational Paralinguistic Tasks
Sensors, 2023 The field of computational paralinguistics emerged from automatic speech processing, and it covers a wide range of tasks involving different phenomena present in human speech.
Mercedes Vetráb, Gábor Gosztolya
doaj +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Semantic search using protein large language models detects class II microcins in bacterial genomes
mSystemsClass II microcins are antimicrobial peptides that have shown some potential as novel antibiotics. However, to date, only 10 class II microcins have been described, and the discovery of novel microcins has been hampered by their short length and high ...
Anastasiya V. Kulikova +3 more
doaj +1 more source
Semi-Supervised Convolutional Neural Network for Law Advice Online
Applied Sciences, 2019 With the rapid developments of Internet technology, a mass of law cases is constantly occurring and needs to be dealt with in time. Automatic classification of law text is the most basic and critical process in the online law advice platform. Deep neural
Fen Zhao +4 more
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
IEEE AccessTokenization is an important early step in natural language processing (NLP) tasks. The idea is to split the input sentence into smaller units, called tokens, for further processing.
Dorieh Alomari, Irfan Ahmad
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Extended Factorization Machines for Sequential Recommendation
IEEE Access, 2020 Users' historical activities are usually contained in real-life sequential recommendation systems to predict their future behaviors. In this situation, traditional Factorization Machines (FMs) approaches may be not suitable.
Nuan Wen, Fang Zhang
doaj +1 more source