Results 61 to 70 of about 535,963 (306)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Node Embeddings via Neighbor Embeddings
Trans. Mach. Learn. Res.Accepted to Transactions of Machine Learning Research (TMLR)
Jan Niklas Böhm +5 more
openaire +5 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Hoehnea, 2019 Glycol methacrylate resin is a very convenient medium used for inclusions of various types of tissue for histological and cytological studies. It provides excellent mechanical support in the sectioning of samples, even the ones with big differences in ...
Carlos André Espolador Leitão
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
The production of relative clauses in Italian-speaking children with DLD
IsoglossChildren with Developmental Language Disorder (DLD) have been shown to struggle with the acquisition of complex structures requiring structural embedding and movement of a sentential element from its original position. This study examines the production
Fabrizio Arosio +2 more
doaj +1 more source
Journal of Dairy Science, 2023 : In this study, transglutaminase (TG), glucono-δ-lactone (GDL), and citric acid (CA) were used to induce the formation of whey protein isolate (WPI)-milk fat emulsion gels to embed lutein, and the emulsion gels induced in different ways were used for ...
Hongjuan Li +8 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A protocol for high-quality sectioning for tree-ring anatomy
Frontiers in Plant ScienceQuantitative wood anatomy (QWA), which involves measuring wood cell anatomical characteristics commonly on dated tree rings, is becoming increasingly important within plant sciences and ecology.
Marina V. Fonti +19 more
doaj +1 more source