Results 91 to 100 of about 102,869 (305)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

p -embeddings

Topology and its Applications, 2013
In 2013, the authors introduced the notion of \(p\)-extension of rings [Contemporary Mathematics 609, 19--32 (2014; Zbl 1302.13012)]. An extension of rings \(R \hookrightarrow S\) is a \(p\)-extension if for each \(s\in S\) there is an \(r\in R\) such that \(sS = rS\).
Bhattacharjee, Papiya, Knox, Michelle L., McGovern, Warren Wm.   +2 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Def2Vec : a model to extract word embeddings from dictionary definitions

, 2021
LAUREA MAGISTRALEIl sistema più diffuso per rappresentare le parole di un testo al fine di elaborare dei contenuti in linguaggio naturale è l'uso dei word embeddings.
Morazzoni, Irene
core  

Exploring Data Analysis Methods in Generative Models: From Fine-Tuning to RAG Implementation

Computers
The exponential growth in data from technological advancements has created opportunities across fields like healthcare, finance, and social media, but sensitive data raise security and privacy challenges.
Bogdan Mihai Guțu, Nirvana Popescu
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

bio-ontology-research-group/el-embeddings: Embeddings for ontologies in the Description Logic EL++

, 2019
Embeddings for ontologies in the Description Logic EL+
Kulmanov, Maxat, Liu-Wei, Wang, Yan, Yuan, Hoehndorf, Robert   +3 more
core  

Safeguarding the Integrity of Online Social Networks (OSN): Leveraging the Efficacy of Conv-LSTM-Based Siamese Network to Predict Hate Speech in Low Resource Hindi-English Code-Mixed Text

IEEE Access
In the era of free speech and rapid internet expansion, curbing the dissemination of offensive content on social media has become a pressing concern for linguists and regulatory bodies.
Shankar Biradar, Sunil Saumya, Sanjana Kavatagi   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source