Results 111 to 120 of about 102,869 (305)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Joint-Tree Model and the Maximum Genus of Graphs [PDF]
, 2012 In 1971, Nordhaus, Stewart and White introduced the idea of the maximum genus of graphs.Since then many researchers have paid attention to this object and obtained many interesting results.
Dong, Guanghua +3 more
core +1 more source
Joint Cloud-Resilient Super-Resolution and Restoration Using AlphaEarth Foundation Embeddings
IEEE AccessSatellite-based remote sensing is a valuable source of spatial data for monitoring vast territories, yet the availability of high-resolution (HR) imagery remains a major bottleneck.
Evgeny Burnaev +8 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Italian word embeddings and machine translation: application in the biomedical field
, 2023 LAUREA MAGISTRALENel settore biomedico, la digitalizzazione dei processi clinici e dei servizi sanitari ha portato le strutture a produrre e archiviare una grande quantità di dati medici, in gran parte di natura testuale.
BAVARO, MARCELLO
core
Proceedings of the American Mathematical Society, 1973 In this paper we generalize the notion of exact functor to an arbitrary category and show that every small category has a full embedding into a category of all set-valued functors on some small category. The notion of exact is such that this result generalizes the author’s exact embedding of regular categories and, indeed, Mitchell’s embedding of ...
openaire +1 more source
Journalism and MediaRecent journalism and media research increasingly uses embeddings, transformer-based models, and large language models, yet the methodological functions remain unevenly conceptualized.
Amaia Perez-de-Arriluzea-Madariaga +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Joint Representation Learning for Retrieval and Annotation of Genomic Interval Sets
BioengineeringAs available genomic interval data increase in scale, we require fast systems to search them. A common approach is simple string matching to compare a search term to metadata, but this is limited by incomplete or inaccurate annotations. An alternative is
Erfaneh Gharavi +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source