Results 111 to 120 of about 6,228 (205)

Regional manifold learning for disease classification. [PDF]

IEEE Trans Med Imaging, 2014
Ye DH, Desjardins B, Hamm J, Litt H, Pohl KM.   +4 more
europepmc   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source

Trophic and tectonic limits to the global increase of marine invertebrate diversity. [PDF]

Sci Rep, 2017
Cermeño P, Benton MJ, Paz Ó, Vérard C.   +3 more
europepmc   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Joint learning of nonlinear representation and projection for fast constrained MRSI reconstruction. [PDF]

Magn Reson Med
Li Y, Ruhm L, Wang Z, Zhao R, Anderson A, Arnold P, Huesmann G, Henning A, Lam F.   +8 more
europepmc   +1 more source

Manifold parametrizations by eigenfunctions of the Laplacian and heat kernels. [PDF]

Proc Natl Acad Sci U S A, 2008
Jones PW, Maggioni M, Schul R.
europepmc   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Application of UMAP to identify refined gold sources using chemical composition analysis. [PDF]

Sci Rep
Verbel AA, Gregory DD, Schutesky ME, Thompson J, McInnes L, Figueroa MA, Moreira-Lima EA, Tadao-Joko C.   +7 more
europepmc   +1 more source

Content-based image retrieval of digitized histopathology in boosted spectrally embedded spaces. [PDF]

J Pathol Inform, 2015
Sridhar A, Doyle S, Madabhushi A.
europepmc   +1 more source