Results 71 to 80 of about 2,359,808 (286)

Historic Scotland Technical Paper 13:Embodied Energy Considerations for Historic Buildings [PDF]

, 2011
This report outlines the importance of life cycle analysis (LCA) in assessing the sustainability of new buildings and of maintaining, refurbishing and replacing existing buildings.
Menzies, Gillian Frances
core  

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Cradle-to-Gate Assessment and Mitigation of Embodied Carbon in Commercial Buildings

Buildings
According to the U.S. Environmental Protection Agency (2024), carbon dioxide is the leading greenhouse gas driving global warming. The building sector accounts for about 39% of global energy-related carbon emissions, with 11% from embodied carbon ...
Khulood Al Rifaie, Taher Abu-Lebdeh, Nihal Al Raees, Ashraf A. M. Fadiel   +3 more
doaj   +1 more source

Optimizing Structural Grids in Concrete Buildings: A BIM-Based Multi-Objective Assessment of Cost and Embodied Carbon [PDF]

JES: Journal of Engineering Sciences
Reducing embodied carbon in concrete buildings is increasingly critical as operational emissions fall, yet early structural-grid decisions are typically driven by cost with limited carbon visibility.
Bahy Labib Elgendy, Aya Elhozayen
doaj   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Using Green Infrastructure to Create Carbon Neutral Cities: An Accounting Methodology

Chemical Engineering Transactions, 2020
Many cities across the world have the aspiration to be carbon neutral. However, this requires energy efficient buildings and the implementation of green infrastructure.
Simon Beecham
doaj   +1 more source

Embodied carbon dioxide as a design tool – a case study

, 2011
Embodied carbon dioxide is increasingly being used to measure the sustainability of a building’s structure. With reference to the West Kowloon terminus in Hong Kong, this paper outlines how estimates of embodied carbon dioxide were used as a design tool
David Knight, Bill Addis
core   +1 more source

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi, Mohanad A. Alkuwaiti, Yazeed B. Alaql, Ahmed K. Alsaif, Ahmed A. Alessa, Meshari Ayed Alharbi, Mohammed Alfalah, Saud A. Alnaaim, Sajjad M. AlHaddad, Ahmed Y. Azzam   +9 more
wiley   +1 more source

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

Arthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo, Ashish P. Balar, Aidan K. Strother, Subhash Kulkarni, Michael Hughes, Brian Skaug, Maureen D. Mayes, Shervin Assassi, Ali Y. Ayla, Zsuzsanna H. McMahan   +9 more
wiley   +1 more source