Results 41 to 50 of about 4,214 (266)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Embodied GHG emissions of building materials in Shanghai [PDF]

Journal of Cleaner Production, 2019
The tremendous use of building materials poses heavy threats to resources and the environment. In order to better understand the GHG emissions embodied in the abundant building material consumption of Shanghai's buildings and search for approaches to reduce GHG emissions, this study explores the building consumption and the embodied GHG emission in ...
Huang, B, Chen, Y, McDowall, W, Türkeli, S, Bleischwitz, R, Geng, Y   +5 more
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Material requirements for future low-carbon electricity projections in Africa

Energy Strategy Reviews, 2022
Deploying low-carbon electricity systems in developing countries is critical for meeting climate targets while increasing wellbeing. Direct emissions from operating electricity generation are well-understood, however, materials required to construct ...
Karla Cervantes Barron, Maaike E. Hakker, Jonathan M. Cullen   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A comprehensive tool for embodied carbon quantification and supporting mitigation strategies in the Building sector

Discover Applied Sciences
The building sector is a significant contributor to global greenhouse gas (GHG) emissions, with emissions classified into operational and embodied carbon.
Miguel Martinho, Joana Fernandes, Ricardo Gomes, Paulo Lourador, Paulo Ferrão   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Optimizing building solutions in a changing climate: parameter-based analysis of embodied and operational environmental impacts

Environmental Research: Infrastructure and Sustainability, 2023
Buildings contribute significantly to global energy consumption and carbon dioxide emissions. Climate change affects building performance, particularly heating and cooling demands. While current policies focus on improving energy performance and reducing
Delphine Ramon, Karen Allacker
doaj   +1 more source

Spatial-temporal changes of land-use mercury emissions in China

Ecological Indicators, 2023
Land use change is closely related to human activities, and has significant impacts on pollutant emissions. Mercury (Hg) is the most toxic heavy metal element gas damaging the environment severely, and China has the largest mercury emissions.
Shan Guo, Yang Wang
doaj   +1 more source