Results 41 to 50 of about 9,022 (301)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

A Consumption-Based Approach to Carbon Emission Accounting – Sectoral Differences and Environmental Benefits

open access: yes, 2013
In recent years there has been growing concern about the emission trade balances of countries. This is due to the fact that countries with an open economy are active players in international trade.
Vetőné Mózner, Zsófia
core   +1 more source

Life Cycle Assessment of Embodied Carbon in Buildings: Background, Approaches and Advancements

open access: yesBuildings, 2022
The environment demands a reduction in greenhouse gas (GHG) emissions, as building and construction are responsible for more than 40% of the energy consumed worldwide and 30% of the world’s GHG emissions.
Sahil Ali Khan   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Lifecycle CO2 Reduction by Implementing Double Window Casement Systems in Residential Units in Korea

open access: yesEnergies, 2015
This study investigated lifecycle CO2 (LCCO2) emission reductions through application of double-window casement systems (DWCS) in residential units in Korea, compared with conventional single windows (SWs).
Chang Heon Cheong   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

CO2 Emissions embodied in China's Trade and Reduction Policy Assessment [PDF]

open access: yes, 2023
China is the world’s largest emitter of carbon dioxide (CO2) and is one of the world’s largest exporters. In 2007, CO2 emissions embodied in China’s net exports totaled 1176 million metric tons (mmt), accounting for 22% of China’s CO2 emissions.
Winchester, Niven   +3 more
core   +1 more source

Material requirements for future low-carbon electricity projections in Africa

open access: yesEnergy Strategy Reviews, 2022
Deploying low-carbon electricity systems in developing countries is critical for meeting climate targets while increasing wellbeing. Direct emissions from operating electricity generation are well-understood, however, materials required to construct ...
Karla Cervantes Barron   +2 more
doaj   +1 more source

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