Results 51 to 60 of about 9,022 (301)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A comprehensive tool for embodied carbon quantification and supporting mitigation strategies in the Building sector

Discover Applied Sciences
The building sector is a significant contributor to global greenhouse gas (GHG) emissions, with emissions classified into operational and embodied carbon.
Miguel Martinho, Joana Fernandes, Ricardo Gomes, Paulo Lourador, Paulo Ferrão   +4 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Linking NAMEA and Input output for 'consumption vs. production perspective' analyses [PDF]

We integrate input output and NAMEA tables for Spain and Italy in 1995, 2000 and 2005, in order to address the hot policy issue of sustainable consumption and production.
Massimiliano Mazzanti, Giovanni Marin, Anna Montini   +2 more
core   +2 more sources

Optimizing building solutions in a changing climate: parameter-based analysis of embodied and operational environmental impacts

Environmental Research: Infrastructure and Sustainability, 2023
Buildings contribute significantly to global energy consumption and carbon dioxide emissions. Climate change affects building performance, particularly heating and cooling demands. While current policies focus on improving energy performance and reducing
Delphine Ramon, Karen Allacker
doaj   +1 more source

Spatial-temporal changes of land-use mercury emissions in China

Ecological Indicators, 2023
Land use change is closely related to human activities, and has significant impacts on pollutant emissions. Mercury (Hg) is the most toxic heavy metal element gas damaging the environment severely, and China has the largest mercury emissions.
Shan Guo, Yang Wang
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Embodied carbon costs of prefabricated substation buildings

Low-Carbon Materials and Green Construction
Exploring the economic impacts of embodied carbon emissions is significant for achieving sustainable development in construction projects. However, the quantitative assessment of carbon costs in prefabricated buildings remains lacking.
Xilong Chen, Xian Gao, Kun Lu, Xueyuan Deng   +3 more
doaj   +1 more source

Embodied Energy and CO₂ Emissions of Widely Used Building Materials: The Ethiopian Context

Buildings, 2019
Buildings use a wide range of construction materials, and the manufacturing of each material consumes energy and emits CO2. Several studies have already been conducted to evaluate the embodied energy and the related CO2 emissions of building materials ...
Woubishet Zewdu Taffese, Kassahun Admassu Abegaz   +1 more
doaj   +1 more source

An Analysis of the Responsibilities and Driving Factors for Embodied Carbon in Trade

Chinese Journal of Urban and Environmental Studies, 2022
By adopting the consumption-based accounting (CBA) method of carbon emissions based on national carbon intensity (NCI), using the International Trade Centre (ITC) database, the Emissions Database for Global Atmospheric Research (EDGAR), and the World ...
Bin ZHANG, Liping LI, Jia ZHAO, Li ZHANG
doaj   +1 more source