Results 181 to 190 of about 316,204 (264)

When Fertilization Is Not Enough: Maternal-Zygotic Transition as a Determinant of Embryo Competence in IVF. [PDF]

Int J Mol Sci
Voros C, Chatzinikolaou F, Papadimas G, Gunes AC, Koulakmanidis AM, Papapanagiotou I, Karpouzos A, Athanasiou D, Bananis K, Athanasiou A, Athanasiou A, Tsimpoukelis C, Daskalaki MA, Trakatelli CM, Thomakos N, Antsaklis P, Loutradis D, Daskalakis G.   +17 more
europepmc   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Phylogenetic analysis of CIAV and pathogenies in embryo eggs. [PDF]

Poult Sci
Xie Y, Chen Q, Chen Z, Liang H, Chen Z, Xie H, Wu H.   +6 more
europepmc   +1 more source

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

Construction and validation of a preimplantation kinship identification model using ultra-low-depth whole genome sequencing. [PDF]

iScience
Lu J, Lin J, Hu R, Wu F, Li Y, Huang H, Wang S, Tian M, Qi Y, Zhao X, Chen Y, Wu J.   +11 more
europepmc   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Single or Double Embryo Transfer for Infertility: An Evaluation of Registry Data From Over 22 000 Treatment Cycles. [PDF]

Dtsch Arztebl Int
Krüssel JS, Kimmel M, Czeromin U, Blumenauer V, Bartnitzky S, Sänger N, Fehr D, Grewe C, Kupka MS, Tauchert S, Aust H, Tandler-Schneider A.   +11 more
europepmc   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Pharmacodynamic interaction analysis of dydrogesterone, progesterone, and estradiol in combination-progestin HRT frozen embryo transfer: a prospective clinical cohort study. [PDF]

Reprod Biol Endocrinol
Eggersmann TK, Hamala N, Hiller RAF, Depenbusch M, Schultze-Mosgau A, Edimiris P, Baston-Buest D, Bielfeld AP, Kruessel JS, von Otte S, Junkers W, Tauchert S, Vonthein R, Griesinger G.   +13 more
europepmc   +1 more source