Results 201 to 210 of about 316,204 (264)

Two Routes to Land: Genomic Underpinnings of Parallel Aerial Egg Deposition in Aquatic Old‐World Pila and New‐World Pomacea (Ampullariidae)

Advanced Science, EarlyView.
Comparative genomics of Gondwana‐diverged Pila and Pomacea reveals parallel evolution of aerial oviposition. Convergent chromosomal rearrangements reshape regulatory landscapes within topologically associating domains. Lineage‐specific gene family expansions and viral‐derived perivitelline proteins (PV1) underpin desiccation resistance.
Yufei Zhou, Huawei Mu, Xueying Nie, Yue Gao, Hui Wang, Ling Fang, Tiangang Luan, Monthon Ganmanee, Jian‐Wen Qiu, Jin Sun, Jack Chi‐Ho Ip   +10 more
wiley   +1 more source

Development of an oscillating magnetic field-assisted supercooling system for bovine embryo preservation. [PDF]

J Anim Sci Technol
So JH, Ju BH, Joe SY, Ko Y, Jun S, Kim MK, Lee SH.   +6 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Explainable Artificial Intelligence in Assisted Reproductive Technology: Bridging Prediction and Clinical Judgment. [PDF]

Biomedicines
Kritsotaki N, Diamantidis D, Koutlaki N, Machairiotis N, Tsikouras P.   +4 more
europepmc   +1 more source

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

LH supplementation in ovarian stimulation: propensity score and generalized estimating equations analysis over 2000 embryos. [PDF]

Front Endocrinol (Lausanne)
Dizdar M, Boynukalın FK, Dündar B, Gültomruk M, Kale İ, Yarkıner Z, Bahçeci M, Polyzos NP, Bozdağ G.   +8 more
europepmc   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Protocol for intracardiac delivery and live imaging of NK-tumor interactions in an ex ovo chick embryo model. [PDF]

STAR Protoc
Saari M, Järvelä E, Ali T, Siddiqui H, Göös H, Korhonen M, Schenkwein D, Ylä-Herttuala S, Vainio S, Skovorodkin I, Jahan F.   +10 more
europepmc   +1 more source

Dual Cytoplasmic and Chloroplastic Mechanisms Fine‐Tune Chloroplast Division through ARC3 Protein Stability

Advanced Science, EarlyView.
ARC3 levels are controlled by cytosolic and chloroplast proteolytic systems. PUB52 mediates ARC3 precursor ubiquitination and degradation in the cytosol, while CLPC1 promotes ARC3 degradation in chloroplasts, where ARC2 protects ARC3 from excessive breakdown. Disrupting these components causes chloroplast division defects, placing them upstream of ARC3.
Yang Yuan, Denghao Xiang, Ruiying Li, Zhichuang Yue, Zhipeng Wang, Honghong Hu   +5 more
wiley   +1 more source

Human stem cell-based embryo models: innovation, ethics, and policy. [PDF]

Hum Reprod
Arias AM, Rivron N, Tajbakhsh S, Johnston J, Alev C, Bally-Cuif L, Böke E, Cavazza T, Cave E, Cyranoski D, David L, Esteban MA, Fu J, Geijsen N, de Graeff N, Hanna JH, Hopwood N, Inamdar MS, Lanner F, Leeners B, Liu Z, Jean Leon M, Minchiotti G, Moris N, Munsie M, Niakan KK, Pourquie O, Pasque V, Pera M, Peng Y, Petropoulos S, Ramanathan S, Rossant J, Rugg-Gunn P, Saitou M, Sermon K, Silva J, Theunissen T, Turco M, Wallingford J, Wang H, Warmflash A, Wu J, Yu L.   +43 more
europepmc   +1 more source