Results 41 to 50 of about 444,108 (317)

Filtered reproductive long non-coding RNAs by genome-wide analyses of goat ovary at different estrus periods

BMC Genomics, 2018
Background The goat is an important farm animal. Reproduction is an important process of goat farming. The ovary is the most important reproductive organ for goats.
Yong Liu, Bing Qi, Juan Xie, Xiaoqing Wu, Yinghui Ling, Xinyan Cao, Feng Kong, Jing Xin, Xin Jiang, Qiaoqin Wu, Wenying Wang, Qingmei Li, Shengnan Zhang, Fengrui Wu, Di Zhang, Rong Wang, Xiaorong Zhang, Wenyong Li   +17 more
doaj   +1 more source

[Chimeric embryos and pseudo-embryos: An alternative to human embryos for research].

Medecine sciences : M/S, 2021
L’étude du développement humain est indispensable afin d’approfondir nos connaissances et, à long terme, perfectionner nos stratégies thérapeutiques dans les domaines de la médecine de la reproduction et de la médecine régénératrice. Face à la limite d’accès aux embryons surnuméraires et à l’interdiction d’en créer de nouveaux seulement à des fins de ...
Savatier, Pierre, David, Laurent, de Vos, John, Yates, Frank, Tajbakhsh, Shahragim, Martinat, Cécile   +5 more
openaire   +2 more sources

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Transcriptional defects and reprogramming barriers in somatic cell nuclear reprogramming as revealed by single-embryo RNA sequencing

BMC Genomics, 2018
Background Nuclear reprogramming reinstates totipotency or pluripotency in somatic cells by changing their gene transcription profile. This technology is widely used in medicine, animal husbandry and other industries.
Yong Liu, Fengrui Wu, Ling Zhang, Xiaoqing Wu, Dengkun Li, Jing Xin, Juan Xie, Feng Kong, Wenying Wang, Qiaoqin Wu, Di Zhang, Rong Wang, Shaorong Gao, Wenyong Li   +13 more
doaj   +1 more source

Long Non-Coding RNA and mRNA Profiling in Early-Stage Bovine Embryos Treated with Glutathione

Antioxidants, 2020
We measured differential expression profiles of genes and long non-coding RNA (lncRNA) using RNA sequencing in bovine embryos with or without glutathione (GSH) treatment. Bovine embryos fertilized in vitro were treated with GSH to blastocyst.
Qinqin Guo, Lixin Cui, Weijun Sun, Feng Li, Haisheng Hao, Xueming Zhao, Huabin Zhu, Weihua Du   +7 more
doaj   +1 more source

MYBPC3 deficiency in cardiac fibroblasts drives their activation and contributes to fibrosis

Cell Death and Disease, 2022
Genetic mutations in the MYBPC3 gene encoding cardiac myosin binding protein C (cMyBP-C) are the most common cause of hypertrophic cardiomyopathy (HCM). Myocardial fibrosis (MF) plays a critical role in the development of HCM.
Xiaodong Zou, Hongsheng Ouyang, Feng Lin, Huanyu Zhang, Yang Yang, Daxin Pang, Renzhi Han, Xiaochun Tang   +7 more
doaj   +1 more source

Single-Step Genomic Prediction of Superovulatory Response Traits in Japanese Black Donor Cows

Biology, 2023
We assessed the performance of single-step genomic prediction of breeding values for superovulatory response traits in Japanese Black donor cows. A total of 25,332 records of the total number of embryos and oocytes (TNE) and the number of good embryos ...
Atsushi Zoda, Shinichiro Ogawa, Rino Kagawa, Hayato Tsukahara, Rui Obinata, Manami Urakawa, Yoshio Oono   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source