Results 41 to 50 of about 740,021 (309)

Truncated C-terminus of fibrillin-1 induces Marfanoid-progeroid-lipodystrophy (MPL) syndrome in rabbit

open access: yesDisease Models & Mechanisms, 2018
Various clinical differences have been observed between patients with the FBN1 gene mutation and those with the classical Marfan phenotype. Although FBN1 knockout (KO) or dominant-negative mutant mice are widely used as an animal model for Marfan ...
Mao Chen   +12 more
doaj   +1 more source

Fixed versus flexible antagonist protocol in women with predicted high ovarian response except PCOS: a randomized controlled trial

open access: yesBMC Pregnancy and Childbirth, 2021
Background No previous study directly compares the fixed day-5 initiation versus the flexible initiation of GnRH antagonist administration in IVF/ICSI for those patients who are predicted as high ovarian responders without PCOS.
Xiu Luo   +5 more
doaj   +1 more source

Impact of Maternal Age on Oocyte and Embryo Competence

open access: yesFrontiers in Endocrinology, 2018
The overall success of human reproduction, either spontaneously or after IVF, is highly dependent upon maternal age. The main reasons for age-related infertility include reduced ovarian reserve and decreased oocyte/embryo competence due to aging insults,
D. Cimadomo   +5 more
semanticscholar   +1 more source

An immunological approach of sperm sexing and different methods for identification of X- and Y-chromosome bearing sperm [PDF]

open access: yesVeterinary World, 2017
Separation of X- and Y-chromosome bearing sperm has been practiced for selection of desired sex of offspring to increase the profit in livestock industries. At present, fluorescence-activated cell sorter is the only successful method for separation of X-
Shiv Kumar Yadav   +10 more
doaj   +1 more source

Oocyte, embryo and blastocyst cryopreservation in ART: systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance

open access: yesHuman Reproduction Update, 2016
BACKGROUND Successful cryopreservation of oocytes and embryos is essential not only to maximize the safety and efficacy of ovarian stimulation cycles in an IVF treatment, but also to enable fertility preservation.
L. Rienzi   +7 more
semanticscholar   +1 more source

Optimization of a CRISPR/Cas9-mediated Knock-in Strategy at the Porcine Rosa26 Locus in Porcine Foetal Fibroblasts

open access: yesScientific Reports, 2017
Genetically modified pigs have important roles in agriculture and biomedicine. However, genome-specific knock-in techniques in pigs are still in their infancy and optimal strategies have not been extensively investigated.
Zicong Xie   +11 more
doaj   +1 more source

Analysis of DNA methylation profiles during sheep skeletal muscle development using whole-genome bisulfite sequencing

open access: yesBMC Genomics, 2020
Background DNA methylation is an epigenetic regulatory form that plays an important role in regulating the gene expression and the tissues development.. However, DNA methylation regulators involved in sheep muscle development remain unclear.
Yixuan Fan   +6 more
doaj   +1 more source

Review: Recent advances in bovine in vitro embryo production: reproductive biotechnology history and methods.

open access: yesAnimal, 2019
In vitro production (IVP) of embryos and associated technologies in cattle have shown significant progress in recent years, in part driven by a better understanding of the full potential of these tools by end users.
L. Ferré   +5 more
semanticscholar   +1 more source

Oct4 regulates DNA methyltransferase 1 transcription by direct binding of the regulatory element

open access: yesCellular & Molecular Biology Letters, 2018
Background The transcription factor Oct4 plays a pivotal role in the pre-implantation development of the mouse embryo. DNA methyltransferase 1 (Dnmt1) maintains the changes in DNA methylation during mammalian early embryonic development.
Fengrui Wu   +6 more
doaj   +1 more source

Activation and Inhibition of The Wnt3A Signaling Pathway in Buffalo (Bubalus bubalis) Embryonic Stem Cells: Effects of WNT3A, Bio and Dkk1 [PDF]

open access: yesInternational Journal of Fertility and Sterility, 2015
Background This research studies the effects of activation and inhibition of Wnt3A signaling pathway in buffalo (Bubalus bubalis) embryonic stem (ES) cell-like cells.
Mohammad Zandi   +7 more
doaj   +1 more source

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