Results 41 to 50 of about 481,641 (307)

AMH regulates granulosa cell function via ESR2/ p38-MAPK signaling pathway in sheep

Communications Biology
Anti-Müllerian Hormone (AMH), secreted by granulosa cells (GCs) of preantral follicles, regulates early-stage follicle growth by inhibiting the activation of primordial follicles.
Hui Xu, Yu Cai, Hua Yang, Chong Zhang, Wanru Liu, Binru Zhao, Feng Wang, Yanli Zhang   +7 more
doaj   +1 more source

Highly efficient RNA-guided base editing in rabbit

Nature Communications, 2018
Base editors can make targeted changes without inducing a double-stranded break. Here, the authors apply the BE3 and ABE7.10 systems to rabbit to create highly efficient targeted base substitutions and various mutation types, and show reduced frequency ...
Zhiquan Liu, Mao Chen, Siyu Chen, Jichao Deng, Yuning Song, Liangxue Lai, Zhanjun Li   +6 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos [PDF]

, 2012
Background The aetiology of recurrent miscarriage (RM) remains largely unexplained. Women with RM have a shorter time to pregnancy interval than normally fertile women, which may be due to more frequent implantation of non-viable embryos.
Weimar, Charlotte H. E., Gellersen, Birgit, Heijnen Cobi J., Johanna M T de Vreeden-Elbertse, Jan J. Brosens (109247), de Vreeden-Elbertse Johanna M. T., de Vreeden-Elbertse, Johanna M.T., Nick S Macklon, Macklon Nick S., Kavelaars, Annemieke, Charlotte H. E. Weimar (148304), Nick S. Macklon (148320), Jan J Brosens, Weimar Charlotte H. E., Gellersen Birgit, Cobi J. Heijnen (148314), Brosens Jan J., Macklon, Nick S., Weimar, Charlotte H.E., Kavelaars Annemieke, Cobi J Heijnen, Charlotte H E Weimar, Birgit Gellersen (148307), de Vreeden-Elbertse, Johanna M. T., Brosens, Jan J., Heijnen, Cobi J., Annemieke Kavelaars, Annemieke Kavelaars (12570), Birgit Gellersen, Johanna M. T. de Vreeden-Elbertse (148309)   +29 more
core   +2 more sources

Oct4 regulates DNA methyltransferase 1 transcription by direct binding of the regulatory element

Cellular & Molecular Biology Letters, 2018
Background The transcription factor Oct4 plays a pivotal role in the pre-implantation development of the mouse embryo. DNA methyltransferase 1 (Dnmt1) maintains the changes in DNA methylation during mammalian early embryonic development.
Fengrui Wu, Qingqing Wu, Dengkun Li, Yuan Zhang, Rong Wang, Yong Liu, Wenyong Li   +6 more
doaj   +1 more source

The Study of Alternative Splicing Events in Human Induced Pluripotent Stem Cells From a Down's Syndrome Patient

Frontiers in Cell and Developmental Biology, 2021
Down's syndrome (DS) is one of the most commonly known disorders with multiple congenital disabilities. Besides severe cognitive impairment and intellectual disability, individuals with DS also exhibit additional phenotypes of variable penetrance and ...
Yunjie Wang, Yunjie Wang, Zexu Li, Zexu Li, Guanheng Yang, Guanheng Yang, Linlin Cai, Linlin Cai, Fan Yang, Fan Yang, Yaqiong Zhang, Yaqiong Zhang, Yitao Zeng, Yitao Zeng, Qingwen Ma, Qingwen Ma, Fanyi Zeng, Fanyi Zeng, Fanyi Zeng   +18 more
doaj   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Cloning of embryos [PDF]

Bioscientifica Proceedings, 2020
Nuclear transfer for the study of differentiation in amphibians has been used since the 1950s, but not until recently have the same procedures been applied successfully to some mammals. Nuclear transfer, as developed for the amphibian, is successful in sheep, cattle, rabbit, and pig, but not mouse embryos.
R S, Prather, N L, First
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

LncRNA and mRNA expression characteristics and bioinformatics analysis of exosomes from sheep ovaries with different reproductive capacities

Scientific Data
Hu sheep (HS) is known for its year-round estrus and multiple births, and is an ideal model for studying the mechanisms of high reproductive capacity in livestock.
Chenbo Yan, Chong Zhang, Wurilege Wei, Tianning Dong, Yanli Zhang   +4 more
doaj   +1 more source