Results 201 to 210 of about 106,954 (262)

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

A Comprehensive Comparison of PICSI and ICSI Techniques Through a Triple-Blinded Trial: Effects on Embryo Quality, Cumulative Pregnancy Rate, and Live Birth Rate. [PDF]

Biomedicines
Alegre L, Carrión-Sisternas L, Bori L, Hervás I, Remohí J, Garrido N, Meseguer M.   +6 more
europepmc   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Vitamin C Improves Oocyte In Vitro Maturation and Potentially Changes Embryo Quality in Cattle. [PDF]

Vet Sci
Wang Y, Wang A, Liu H, Yang R, Zhang B, Tang B, Li Z, Zhang X.   +7 more
europepmc   +1 more source

Dual Cytoplasmic and Chloroplastic Mechanisms Fine‐Tune Chloroplast Division through ARC3 Protein Stability

Advanced Science, EarlyView.
ARC3 levels are controlled by cytosolic and chloroplast proteolytic systems. PUB52 mediates ARC3 precursor ubiquitination and degradation in the cytosol, while CLPC1 promotes ARC3 degradation in chloroplasts, where ARC2 protects ARC3 from excessive breakdown. Disrupting these components causes chloroplast division defects, placing them upstream of ARC3.
Yang Yuan, Denghao Xiang, Ruiying Li, Zhichuang Yue, Zhipeng Wang, Honghong Hu   +5 more
wiley   +1 more source

Air pollution exposure in vitrified oocyte donors and male recipient partners in relation to fertilization and embryo quality. [PDF]

Environ Int
LaPointe S, Lee JC, Nagy ZP, Shapiro DB, Chang HH, Wang Y, Russell AG, Hipp HS, Gaskins AJ.   +8 more
europepmc   +1 more source

Study of the Association of Semen Parameters With Embryo Quality in a Tertiary Care Center in Bihar: A Retrospective Study. [PDF]

Cureus
Kumari S, Singh K, Kumar A, Kumari S, Raina A.   +4 more
europepmc   +1 more source

Impact of Amphiregulin on Oocyte Maturation and Embryo Quality: Insights from Clinical and Molecular Perspectives. [PDF]

Geburtshilfe Frauenheilkd
Kljajic M, Ney JT, Wagenpfeil G, Baus S, Solomayer EF, Kasoha M.   +5 more
europepmc   +1 more source

The relationship between serum progesterone level on the day of HCG trigger in IVF/ICSI cycles and oocyte maturation and embryo quality: a retrospective observational study. [PDF]

BMC Womens Health
Hokmabadi E, Salahi E, Ghasemi M.
europepmc   +1 more source

Melatonin levels and embryo quality in IVF patients with diminished ovarian reserve: a comparative study.

Reprod Biol Endocrinol
Wang Y, Liu S, Gan F, Xiong D, Zhang X, Zheng Z.   +5 more
europepmc   +1 more source