Results 1 to 10 of about 16,236,368 (310)

Mechano-biochemical marine stimulation of inversion, gastrulation, and endomesoderm specification in multicellular Eukaryota

Frontiers in Cell and Developmental Biology, 2022
The evolutionary emergence of the primitive gut in Metazoa is one of the decisive events that conditioned the major evolutionary transition, leading to the origin of animal development.
Ngoc Minh Nguyen, Tatiana Merle, Florence Broders-Bondon, Anne-Christine Brunet, Aude Battistella, Emelie Britt Linnea Land, Florian Sarron, Aditya Jha, Jean-Luc Gennisson, Eric Röttinger, Eric Röttinger, María Elena Fernández-Sánchez, Emmanuel Farge   +12 more
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Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors

Nature Communications, 2018
A role for Slit/Robo signalling in pancreas development has not been defined. Here, the authors generate Robo1/Robo2 knockout mice to identify both as needed for establishing initial pancreatic cell identity as well as for proliferation and survival of ...
Sophie Escot, David Willnow, Heike Naumann, Silvia Di Francescantonio, Francesca M. Spagnoli   +4 more
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Identification of hub genes, signaling pathways and immune infiltration of recurrent spontaneous abortion based on bioinformatics analysis with clinical verification

Taiwanese Journal of Obstetrics & Gynecology, 2022
Objective: The present study was aimed to identify hub genes associated with recurrent spontaneous abortion (RSA) via both bioinformatics analysis and clinical verification, also to evaluate the related pathways and immune infiltration situation of RSA ...
Yun-Xi Chen, Qian-Qian Zhang, Chang Ge, Jing Yang   +3 more
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Ret kinase-mediated mechanical induction of colon stem cells by tumor growth pressure stimulates cancer progression in vivo

Communications Biology, 2022
Ho-Bouldoires, Sollier, Zamfirov and Broders-Bondon et al. show that high frequency pulsatile mechanical stresses maintain the physiological level of mice colon stem cells through the mechanosensitive Ret kinase and that Ret activation is elevated in ...
Thanh Huong Nguyen Ho-Bouldoires, Kévin Sollier, Laura Zamfirov, Florence Broders-Bondon, Démosthène Mitrossilis, Sebastian Bermeo, Coralie L. Guerin, Anna Chipont, Gabriel Champenois, Renaud Leclère, Nicolas André, Laurent Ranno, Aude Michel, Christine Ménager, Didier Meseure, Charlie Demené, Mickael Tanter, Maria Elena Fernández-Sánchez, Emmanuel Farge   +18 more
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Developmental potential of aneuploid human embryos cultured beyond implantation

Nature Communications, 2020
Aneuploidy, abnormal chromosome number, is a major cause of early pregnancy loss. Here the authors determine the extent of post-implantation development of human embryos with common aneuploidies in culture, finding developmental arrest of monosomy 21 ...
Marta N. Shahbazi, Tianren Wang, Xin Tao, Bailey A. T. Weatherbee, Li Sun, Yiping Zhan, Laura Keller, Gary D. Smith, Antonio Pellicer, Richard T. Scott, Emre Seli, Magdalena Zernicka-Goetz   +11 more
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Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2

Nature Communications, 2017
Liver and pancreas cells arise from a common endoderm progenitor in the embryo, but what regulates their cell fate is unclear. Here, the authors show that expression of the Three-Amino-acid-Loop-Extension (TALE) homeobox TG-interacting factor 2 (TGIF2 ...
Nuria Cerdá-Esteban, Heike Naumann, Silvia Ruzittu, Nancy Mah, Igor M. Pongrac, Corinna Cozzitorto, Angela Hommel, Miguel A. Andrade-Navarro, Ezio Bonifacio, Francesca M. Spagnoli   +9 more
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Utilizing Playdoh in the Classroom to Construct a 3D Model Depicting Cellular Movements and Tissue Remodeling during Human Gastrulation, Early Organogenesis, and Embryonic Folding

Journal of Microbiology & Biology Education, 2021
In classroom studies of mammalian embryology, students must fully grasp the cellular and tissue remodeling needed to initiate gastrulation to ensure comprehension of forthcoming developmental processes such as tissue specification and organogenesis ...
Ryan Hesterman, Shannon Rose, Will LeFever, Ryan Stewart, Martina Krone, Camryn Holihan, Kristin Ackerman   +6 more
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Alpha-2-macroglobulin is involved in the occurrence of early-onset pre-eclampsia via its negative impact on uterine spiral artery remodeling and placental angiogenesis

BMC Medicine, 2023
Background Pre-eclampsia (PE) is one of the leading causes of maternal and fetal morbidity/mortality during pregnancy, and alpha-2-macroglobulin (A2M) is associated with inflammatory signaling; however, the pathophysiological mechanism by which A2M is ...
Jingyun Wang, Ping Zhang, Mengyuan Liu, Zhengrui Huang, Xiaofeng Yang, Yuzhen Ding, Jia Liu, Xin Cheng, Shujie Xu, Meiyao He, Fengxiang Zhang, Guang Wang, Ruiman Li, Xuesong Yang   +13 more
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Transcription factor OTX2 silences the expression of cleavage embryo genes and transposable elements

The Journal of Reproduction and Development, 2021
Upon mammalian fertilization, zygotic genome activation (ZGA) and activation of transposable elements (TEs) occur in early embryos to establish totipotency and support embryogenesis.
Shi-meng GUO, Ning-hua MEI, Jing YANG, Li-quan ZHOU   +3 more
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Genomic instability in individuals with sex determination defects and germ cell cancer

Cell Death Discovery, 2023
The ability to transmit genetic information through generations depends on the preservation of genome integrity. Genetic abnormalities affect cell differentiation, causing tissue specification defects and cancer.
Maria Krivega, Jutta Zimmer, Anna Slezko, Petra Frank-Herrmann, Julia Rehnitz, Markus Hohenfellner, Markus Bettendorf, Marcin Luzarowski, Thomas Strowitzki   +8 more
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