Results 41 to 50 of about 16,236,368 (310)
Rabs in Signaling and Embryonic Development [PDF]
International Journal of Molecular Sciences, 2020 Rab GTPases play key roles in various cellular processes. They are essential, among other roles, to membrane trafficking and intracellular signaling events. Both trafficking and signaling events are crucial for proper embryonic development. Indeed, embryogenesis is a complex process in which cells respond to various signals and undergo dramatic changes
Sonya Nassari +2 more
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Frontiers in Cell and Developmental Biology, 2023 Recurrent pregnancy loss (RPL) remains an unsolved problem in obstetrics and gynecology, and up to 50% of RPL cases are unexplained. Unexplained RPL (uRPL) is widely considered to be related to an aberrant endometrial microenvironment.
Jin Luo +6 more
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Identification of early onset pre-eclampsia related key genes via bioinformatic analysis
Informatics in Medicine Unlocked, 2022 Background: Pre-eclampsia is a common pregnancy-specific disease. In this study, we used comprehensive bioinformatics to screen key genes related to the development of pre-eclampsia and explore their potential connections. Methods: Two data sets GSE44711
Zhengrui Huang +12 more
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Embryonic mammary gland development
Seminars in Cell & Developmental Biology, 2021 Embryonic mammary gland development involves the formation of mammary placodes, invagination of flask-shaped mammary buds and development of miniature bi-layered ductal trees. Currently there is a good understanding of the factors that contribute to ectodermal cell movements to create these appendages and of pathways that lead to mammary specification ...
Elena, Spina, Pamela, Cowin
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Inhibition of DRP1 Impedes Zygotic Genome Activation and Preimplantation Development in Mice
Frontiers in Cell and Developmental Biology, 2021 Mitochondrion plays an indispensable role during preimplantation embryo development. Dynamic-related protein 1 (DRP1) is critical for mitochondrial fission and controls oocyte maturation.
Yuanyuan Li +4 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine +21 more
wiley +1 more source
Scientific ReportsPregestational diabetes mellitus (PGDM) has an impact on fetal bone formation, but the underlying mechanism is still obscure. Although miRNAs have been extensively investigated throughout bone formation, their effects on fetal bone development caused by ...
Fan Qian +7 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Slow Turning Lateral Vessel Bioreactor Improves Embryoid Body Formation and Cardiogenic Differentiation of Mouse Embryonic Stem Cells. [PDF]
, 2013 Embryonic stem cells (ESCs) have the ability to form aggregates, which are called embryoid bodies (EBs). EBs mimic early embryonic development and are commonly produced for cardiomyogenesis.
Tharasanit, T. +12 more
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Repurposing metformin for treating osteoarthritis via leveraging Nrf2 signaling
Scientific ReportsThere are currently no satisfactory effective treatments for osteoarthritis (OA), the most common degenerative joint disease leading to progressive disability in the elderly population.
Yeyin Zhong +8 more
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