Results 61 to 70 of about 16,236,368 (310)

Reversine inhibits proliferation and induces apoptosis of human osteosarcoma cells through targeting MEK1

Journal of Bone Oncology
Reversine, or 2-(4-morpholinoanilino)-6-cyclohexylaminopurine, is a 2,6-disubstituted purine derivative. This small molecule shows anti-tumor potential by playing a central role in the inhibition of several kinases related to cell cycle regulation and ...
Xianlong Chen, Yeyin Zhong, Simiao Wang, Shujie Xu, Junyuan Chen, Xin Cheng, Xuesong Yang   +6 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Embryonic development of Pachycheles chubutensis (Decapoda: Anomura) [PDF]

, 2009
The different stages of embryonic development of the porcellanid crab Pachycheles chubutensis are described, along with the chronology of each stage at 16±1°C.
Dupré, Enrique, Gonzalez Pisani, Ximena, Rubilar Panasiuk, Cynthia Tamara, Enrique Dupré, Tamara Rubilar, Ximena González-Pisani   +5 more
core   +1 more source

Role of cholesterol in embryonic development [PDF]

The American Journal of Clinical Nutrition, 2000
We showed previously that 3 distal inhibitors of cholesterol synthesis are highly teratogenic in rats. AY 9944 and BM 15766 inhibit 7-dehydrocholesterol reductase, which catalyzes the last step of cholesterol synthesis, and triparanol inhibits Delta(24)-dehydrocholesterol reductase, which catalyzes the last step in another pathway.
C, Roux, C, Wolf, N, Mulliez, W, Gaoua, V, Cormier, F, Chevy, D, Citadelle   +6 more
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice [PDF]

, 2013
International efforts to test gene function in the mouse by the systematic knockout of each gene are creating many lines in which embryonic development is compromised.
Mohun, Timothy, Richard Baldock, Andrew J. Copp, Houart, Corinne, Hurles, Matt E., Hemberger, Myriam, Wolfgang Weninger, James C. Smith, Adams, David J, Shoumo Bhattacharya, Bhattacharya, Shoumo, Corinne Houart, Hurles, Matt E, Weninger, W, Weninger, Wolfgang, Timothy Mohun, Tom Weaver, Adams, David J., Smith, James C., Baldock, Richard, Weaver, T, David J. Adams, Adams, DJ, Houart, C, Baldock, R, Mohun, T, Hemberger, M, Copp, Andrew J., Weaver, Tom, Bhattacharya, S, Smith, JC, Elizabeth Robertson, Robertson, E, Copp, Andrew J, Myriam Hemberger, Copp, AJ, Robertson, Elizabeth, Hurles, ME, Matt E. Hurles   +38 more
core   +1 more source

Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy

MedComm
Dysbiosis refers to the disruption of the gut microbiota balance and is the pathological basis of various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, and ...
Yao Shen, Nairui Fan, Shu‐xia Ma, Xin Cheng, Xuesong Yang, Guang Wang   +5 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Storage of Hatching Eggs : Effects of storage and early incubation conditions on egg characteristics, embryonic development, hatchability, and chicken quality [PDF]

, 2010
Key words: egg storage, embryonic development, albumen quality, hatchability, chick quality It is well known that an increase in the storage duration increases incubation duration and decreases hatchability and chick quality.
Reijrink, I.A.M.
core