Results 61 to 70 of about 773,120 (317)

Embryonic developments [PDF]

Current Biology, 2009
SummaryAs the UK updates its pioneering Human Fertilisation and Embryology Act, legal boundaries for research in the life sciences are redrawn in other countries as well. Michael Gross reports.
openaire   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells [PDF]

, 2006
Embryonic cortical neural stem cells apparently have a transient existence, as they do not persist in the adult cortex. We sought to determine the fate of embryonic cortical stem cells by following Emx1(IREScre); LacZ/EGFP double-transgenic murine cells ...
Seaberg, R.M., Cindi M. Morshead, Morshead, C.M., Kevin R. Jones, Gorski, J.A., Raewyn M. Seaberg, Etienne Labbé, Jessica A. Gorski, Attisano, L., Jones, K.R., Sandrine Willaime-Morawek, Willaime-Morawek, S., Labbé, E., van der Kooy, D., Claudia Batista, Batista, C., Angela Kam, Liliana Attisano, Derek van der Kooy   +18 more
core   +1 more source

The role of SCF ubiquitin-ligase complex at the beginning of life

Reproductive Biology and Endocrinology, 2019
As the largest family of E3 ligases, the Skp1-cullin 1-F-box (SCF) E3 ligase complex is comprised of Cullins, Skp1 and F-box proteins. And the SCF E3 ubiquitin ligases play an important role in regulating critical cellular processes, which promote ...
Jiayan Xie, Yimei Jin, Guang Wang
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Association between mental health and male fertility: depression, rather than anxiety, is linked to decreased semen quality

Frontiers in Endocrinology
BackgroundInfertility is increasingly recognized as a global health issue affecting couples of reproductive age, with male factors contributing to approximately 50% of infertility cases.
Yi Zhang, Yi Zhang, Bei Chen, Bei Chen, Yaqin Wang, Yaqin Wang, Cong Liu, Cong Liu, Jiayi Sun, Jiayi Sun, Zhimo Zhang, Zhimo Zhang, Liangzi Guan, Liangzi Guan, Ke Xiao, Ke Xiao, Ke Xiao, Zhonghai Zhu, Jin Luo, Jin Luo   +19 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Global DNA hypomethylation prevents consolidation of differentiation programs and allows reversion to the embryonic stem cell state. [PDF]

, 2012
DNA methylation patterns change dynamically during mammalian development and lineage specification, yet scarce information is available about how DNA methylation affects gene expression profiles upon differentiation.
Spada, Fabio, Zacher, Benedikt, Leonhardt, Heinrich, Bultmann, Sebastian, Daniela Meilinger, Heinrich Leonhardt (18589), Daniela Meilinger (107843), Schmidt, Christine S., Benedikt Zacher, Fabio Spada (107869), Kerstin C Maier, Martin, Dietmar E., Christine S. Schmidt (107838), Heinrich Leonhardt, Christian Peter, Peter, Christian, Christine S Schmidt, Dietmar E. Martin (107866), Achim Tresch, Fabio Spada, Benedikt Zacher (107847), Maier, Kerstin C., Tresch, Achim, Christian Peter (107860), Meilinger, Daniela, Achim Tresch (107851), Kerstin C. Maier (107856), Dietmar E Martin, Sebastian Bultmann (107841), Sebastian Bultmann   +29 more
core   +1 more source