Results 61 to 70 of about 695,954 (267)

Growth and cardiovascular development are repressed by florfenicol exposure in early chicken embryos

Poultry Science, 2020
Florfenicol (FLO) is one of the most popular antibacterial drugs used in veterinary clinics and aquaculture. The drug was found to decrease the hatchability of eggs laid by treated hens in veterinary clinics and research work.
Dongfang Hu, Fanliang Meng, Yunli Cui, Mei Yin, Hongmei Ning, Zhihong Yin, Lingli Chen, Yaming Ge, Sidang Liu   +8 more
doaj   +1 more source

Effects of Histones on Embryonic Development

Nature, 1964
I HAVE recently examined in detail the effects of actinomycin D, an inhibitor of UNA polymerase and of messenger RNA synthesis, on the development of amphibian eggs1,2. It is now known that histones also inhibit UNA polymerase3,4 and it has been suggested that they could act as the natural regulators of genetic activity5,6; by combining with specific ...
openaire   +3 more sources

MicroRNAs in embryonic stem cells and early embryonic development [PDF]

Journal of Cellular and Molecular Medicine, 2008
Introduction miRNAs in early embryogenesis
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Polystyrene Nanoparticles Disrupt Oxidative Phosphorylation and Impair Placental Development in Mice

Toxics
Background: Microplastics and nanoplastics, as pervasive and persistent environmental pollutants, are raising growing concerns regarding their potential risks to reproductive health, particularly pregnancy outcomes.
Bingyi Wang, Xinyi Xie, Nairui Fan, Qiqi Deng, Nannan Shi, Denglu Long, Weipeng Huang, Siqi Zhu, Zhi Chen, Xin Cheng, Xuesong Yang, Guang Wang, Qihao Zhang   +12 more
doaj   +1 more source

The RhoGAP Stard13 controls insulin secretion through F-actin remodeling

Molecular Metabolism, 2018
Objective: Actin cytoskeleton remodeling is necessary for glucose-stimulated insulin secretion in pancreatic β-cells. A mechanistic understanding of actin dynamics in the islet is paramount to a better comprehension of β-cell dysfunction in diabetes ...
Heike Naumann, Thomas Rathjen, Matthew N. Poy, Francesca M. Spagnoli   +3 more
doaj   +1 more source

The role of retinoic acid in embryonic and post-embryonic development [PDF]

Proceedings of the Nutrition Society, 2000
Retinoic acid (RA) is the bioactive metabolite of vitamin A (retinol) which acts on cells to establish or change the pattern of gene activity. Retinol is converted to RA by the action of two types of enzyme, retinol dehydrogenases and retinal dehydrogenases.
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection during late pregnancy: a report of 18 patients from Wuhan, China

BMC Pregnancy and Childbirth, 2020
Background Compared with Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), Corona Virus Disease 2019(COVID-19) spread more rapidly and widely. The population was generally susceptible.
Lu Zhang, Lan Dong, Lei Ming, Min Wei, Jun Li, Ruheng Hu, Jing Yang   +6 more
doaj   +1 more source