Results 51 to 60 of about 773,120 (317)

Correlations among hope, fertility quality of life and negative emotions for couples undergoing their first in vitro fertilization–embryo transfer: a cross-sectional analysis

Reproductive Health
Background The global incidence of infertility is increasing, and infertility has become an important medical and social issue. With the widespread application of in vitro fertilization-embryo transfer (IVF-ET) technology, the mental health problems of ...
Hui Ye, Jing Zhao, Yujie Zou, Xiaorun Song, Mi Xu, Yu Zhang, Lili Zhang, Gaohua Wang   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells [PDF]

, 2010
hESCs (human embryonic stem cells) offer great potential for pharmaceutical research and development and, potentially, for therapeutic use. However, improvements in cell culture are urgently required to allow the scalable production of large numbers of ...
Baillie, George S., Nicole M. Kane, Fergus R. McKenzie, Kane, N.M., Achamma Abraham, George S. Baillie, Allcock, R.W., John McAbney, Peter Burton, Baillie, G.S., Graeme Milligan, Kane, Nicole M., Houslay, Miles D., Andrew H. Baker, Robert W. Allcock, Gilmour, J., Gilmour, Jane, Mountford, Joanne C., Joanne C. Mountford, Jiang, Zhong, Miles D. Houslay, Adams, D.R., Adams, David R., McAbney, J., McCahill, Angela, Milligan, Graeme, McKenzie, F.R., Burton, Peter, Abraham, Achamma, Baker, Andrew H., McCahill, A., Jane Gilmour, Jiang, Z., Baker, A.H., Mountford, J.C., Angela McCahill, Abraham, A., Houslay, M.D., McAbney, John, McKenzie, Fergus R., Burton, P., David R. Adams, Milligan, G., Allcock, Robert W., Zhong Jiang   +44 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Three-dimensional culture of human embryonic stem cell derived hepatic endoderm and its role in bioartificial liver construction [PDF]

, 2010
The liver carries out a range of functions essential for bodily homeostasis. The impairment of liver functions has serious implications and is responsible for high rates of patient morbidity and mortality.
Greenhough, Sebastian, Medine, Claire N, Hay, David C; id_orcid, Sharma, Ruchi   +3 more
core   +1 more source

Reversine inhibits proliferation and induces apoptosis of human osteosarcoma cells through targeting MEK1

Journal of Bone Oncology
Reversine, or 2-(4-morpholinoanilino)-6-cyclohexylaminopurine, is a 2,6-disubstituted purine derivative. This small molecule shows anti-tumor potential by playing a central role in the inhibition of several kinases related to cell cycle regulation and ...
Xianlong Chen, Yeyin Zhong, Simiao Wang, Shujie Xu, Junyuan Chen, Xin Cheng, Xuesong Yang   +6 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy

MedComm
Dysbiosis refers to the disruption of the gut microbiota balance and is the pathological basis of various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, and ...
Yao Shen, Nairui Fan, Shu‐xia Ma, Xin Cheng, Xuesong Yang, Guang Wang   +5 more
doaj   +1 more source