Results 51 to 60 of about 1,131,459 (308)

Repurposing metformin for treating osteoarthritis via leveraging Nrf2 signaling

Scientific Reports
There are currently no satisfactory effective treatments for osteoarthritis (OA), the most common degenerative joint disease leading to progressive disability in the elderly population.
Yeyin Zhong, Junyuan Chen, Nannan Shi, Jieying Yu, Simiao Wang, Guang Wang, Min Liu, Xuesong Yang, Xin Cheng   +8 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Correlations among hope, fertility quality of life and negative emotions for couples undergoing their first in vitro fertilization–embryo transfer: a cross-sectional analysis

Reproductive Health
Background The global incidence of infertility is increasing, and infertility has become an important medical and social issue. With the widespread application of in vitro fertilization-embryo transfer (IVF-ET) technology, the mental health problems of ...
Hui Ye, Jing Zhao, Yujie Zou, Xiaorun Song, Mi Xu, Yu Zhang, Lili Zhang, Gaohua Wang   +7 more
doaj   +1 more source

Characterizing the zebrafish organizer: microsurgical analysis at the early-shield stage [PDF]

, 1996
The appearance of the embryonic shield, a slight thickening at the leading edge of the blastoderm during the formation of the germ ring, is one of the first signs of dorsoventral polarity in the zebrafish embryo.
Fraser, Scott E., Shih, John
core  

Fast fluorescence microscopy for imaging the dynamics of embryonic development [PDF]

, 2008
Live imaging has gained a pivotal role in developmental biology since it increasingly allows real-time observation of cell behavior in intact organisms.
Bakal C, Berg JM, Bewersdorf J, Born M, Brakenhoff GJ, Carpenter AE, Cecconi C, Chu KK, Egner A, Fraser S, Graf R, Hirose Y, Isalan M, Julien Vermot, Kam Z, Keller PJ, Kulesa PM, Kulesa PM, Lucitti JL, Mathis L, Michael Liebling, Murray JM, Niesner R, Nishiyama M, Nonaka S, Parsons SF, Potter SM, Rueckel M, Satpute‐Krishnan P, Scott E. Fraser, Sisson JH, Soutoglou E, Starkuviene V, Stathopoulos A, Stelzer EHK, Swedlow J, Tallini N, Tanaami T, Thomann D, Verveer PJ, Vonesch C, Wolleschensky R, Yang G, Zamir EA   +43 more
core   +3 more sources

Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation [PDF]

, 2020
Embryonic Stem Cell (ESC) differentiation requires complex cell signalling network dynamics, although the key molecular events remain poorly understood.
Budzyk, Manon, Bustos, Francisco, Fernandez-Alonso, Rosalia, Findlay, Greg M., Helbig, Andreas O., Hukelmann, Jens, Kumar, Pankaj, Lamond, Angus I., Lanner, Fredrik, Petsalaki, Evangelia, Zhou, Houjiang   +10 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Deformation and tension analysis during embryonic development [PDF]

, 2017
The aim of this document is to introduce the reader into the process, through microscopic threedimensional images, of the cellular embryonic deformation of the Drosphila Melanogaster fly through its development.
Brugarolas Roca, Alejandro
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Reversine inhibits proliferation and induces apoptosis of human osteosarcoma cells through targeting MEK1

Journal of Bone Oncology
Reversine, or 2-(4-morpholinoanilino)-6-cyclohexylaminopurine, is a 2,6-disubstituted purine derivative. This small molecule shows anti-tumor potential by playing a central role in the inhibition of several kinases related to cell cycle regulation and ...
Xianlong Chen, Yeyin Zhong, Simiao Wang, Shujie Xu, Junyuan Chen, Xin Cheng, Xuesong Yang   +6 more
doaj   +1 more source