Results 71 to 80 of about 1,131,459 (308)

Nuclear re-organisation of the Hoxb complex during mouse embryonic development [PDF]

, 2005
The spatial and temporal co-linear expression of Hox genes during development is an exquisite example of programmed gene expression. The precise mechanisms underpinning this are not known.
Bickmore, Wendy A, Chambeyron, Séverine, Da Silva, Nelly R, Lawson, Kirstie A   +3 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The role of SCF ubiquitin-ligase complex at the beginning of life

Reproductive Biology and Endocrinology, 2019
As the largest family of E3 ligases, the Skp1-cullin 1-F-box (SCF) E3 ligase complex is comprised of Cullins, Skp1 and F-box proteins. And the SCF E3 ubiquitin ligases play an important role in regulating critical cellular processes, which promote ...
Jiayan Xie, Yimei Jin, Guang Wang
doaj   +1 more source

Gene expression analysis of bovine embryonic disc, trophoblast and parietal hypoblast at the start of gastrulation [PDF]

, 2017
In cattle early gastrulation-stage embryos (Stage 5), four tissues can be discerned: (i) the top layer of the embryonic disc consisting of embryonic ectoderm (EmE); (ii) the bottom layer of the disc consisting of mesoderm, endoderm and visceral hypoblast
Berg, D, Maclean, P, Pfeffer, P, Smith, C   +3 more
core   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Association between mental health and male fertility: depression, rather than anxiety, is linked to decreased semen quality

Frontiers in Endocrinology
BackgroundInfertility is increasingly recognized as a global health issue affecting couples of reproductive age, with male factors contributing to approximately 50% of infertility cases.
Yi Zhang, Yi Zhang, Bei Chen, Bei Chen, Yaqin Wang, Yaqin Wang, Cong Liu, Cong Liu, Jiayi Sun, Jiayi Sun, Zhimo Zhang, Zhimo Zhang, Liangzi Guan, Liangzi Guan, Ke Xiao, Ke Xiao, Ke Xiao, Zhonghai Zhu, Jin Luo, Jin Luo   +19 more
doaj   +1 more source

Joint interpretation of AER/FGF and ZPA/SHH over time and space underlies hairy2 expression in the chick limb [PDF]

, 2012
Embryo development requires precise orchestration of cell proliferation and differentiation in both time and space. A molecular clock operating through gene expression oscillations was first described in the presomitic mesoderm (PSM) underlying periodic ...
Andrade, Raquel P., Palmeirim, Isabel, Sheeba, Caroline J.   +2 more
core   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Analysis of factors associated with IVF/ICSI clinical outcomes in advanced maternal age patients with normal ovarian reserve under the POSEIDON criteria

Frontiers in Endocrinology
BackgroundThere is limited research about the pregnancy outcomes of POSEIDON group 2 patients. This study aims to evaluate the factors related to the clinical outcomes of in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI) in ...
Yicen Meng, Yicen Meng, Yicen Meng, Qianjie Zhang, Qianjie Zhang, Qianjie Zhang, Yixuan Song, Yixuan Song, Yixuan Song, Qian Liu, Qian Liu, Qian Liu, Wei Li, Jing Yang, Jing Yang, Saijiao Li, Saijiao Li   +16 more
doaj   +1 more source