Results 81 to 90 of about 16,236,368 (310)

Three-dimensional culture of human embryonic stem cell derived hepatic endoderm and its role in bioartificial liver construction [PDF]

, 2010
The liver carries out a range of functions essential for bodily homeostasis. The impairment of liver functions has serious implications and is responsible for high rates of patient morbidity and mortality.
Greenhough, Sebastian, Medine, Claire N, Hay, David C; id_orcid, Sharma, Ruchi   +3 more
core   +1 more source

Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation

Nature Communications, 2017
Mechanical signals regulate tissue differentiation but how this triggers downstream biochemical signals is unclear. Here, the authors place micro-magnets in theDrosophilaembryonic epithelia and show this triggers apical pulsations, in turn stabilizing ...
Démosthène Mitrossilis, Jens-Christian Röper, Damien Le Roy, Benjamin Driquez, Aude Michel, Christine Ménager, Gorky Shaw, Simon Le Denmat, Laurent Ranno, Frédéric Dumas-Bouchiat, Nora M. Dempsey, Emmanuel Farge   +11 more
doaj   +1 more source

International cooperation and the challenge of internet accessibility in Caribbean territories: example of a collaborative platform between the University Hospital of Martinique and Ramón González Coro Hospital in Cuba, through the French PRPH-3 program

BMC Medical Education, 2023
Background Martinique shares with the other Caribbean countries specific public health issues, particularly in the diagnostic and therapeutic management of cancer patients.
Rémi Houpert, Thierry Almont, Christian Mésenge, Line Kleinebreil, Laurence Forlini, Bruno Magnone, Vincent Leroux, Mylène Vestris, Christelle Montabord, Jaylin Carmenate, Yaima Galán, Maria Caredad Rubio, Rodolfo Enriquez, Carol Burte, Nicolas Gatimel, Louis Bujan, Norelyakin Kara, Olivier Edwige, Éric Huyghe, Clarisse Joachim, Jacqueline Véronique-Baudin   +20 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Financing the Future with the IDB Group [PDF]

, 2019
Mobilizing resources is critical to the implementation of the 2030 Agenda and multilateral development banks in particular have been called upon to crowd-in additional financing for the Sustainable Development Goals (SDGs).
Inter-American Development Bank
core   +1 more source

Polystyrene Nanoparticles Disrupt Oxidative Phosphorylation and Impair Placental Development in Mice

Toxics
Background: Microplastics and nanoplastics, as pervasive and persistent environmental pollutants, are raising growing concerns regarding their potential risks to reproductive health, particularly pregnancy outcomes.
Bingyi Wang, Xinyi Xie, Nairui Fan, Qiqi Deng, Nannan Shi, Denglu Long, Weipeng Huang, Siqi Zhu, Zhi Chen, Xin Cheng, Xuesong Yang, Guang Wang, Qihao Zhang   +12 more
doaj   +1 more source

The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo

eLife, 2018
In vivo, the primary molecular mechanotransductive events mechanically initiating cell differentiation remain unknown. Here we find the molecular stretching of the highly conserved Y654-β-catenin-D665-E-cadherin binding site as mechanically induced by ...
Jens-Christian Röper, Démosthène Mitrossilis, Guillaume Stirnemann, François Waharte, Isabel Brito, Maria-Elena Fernandez-Sanchez, Marc Baaden, Jean Salamero, Emmanuel Farge   +8 more
doaj   +1 more source

Effects of Histones on Embryonic Development

Nature, 1964
I HAVE recently examined in detail the effects of actinomycin D, an inhibitor of UNA polymerase and of messenger RNA synthesis, on the development of amphibian eggs1,2. It is now known that histones also inhibit UNA polymerase3,4 and it has been suggested that they could act as the natural regulators of genetic activity5,6; by combining with specific ...
openaire   +3 more sources

MicroRNAs in embryonic stem cells and early embryonic development [PDF]

Journal of Cellular and Molecular Medicine, 2008
Introduction miRNAs in early embryogenesis
openaire   +2 more sources

Evolution of embryonic development in nematodes [PDF]

EvoDevo, 2011
Nematodes can be subdivided into basal Enoplea (clades 1 and 2) and more derived Chromadorea (clades 3 to 12). Embryogenesis of Caenorhabditis elegans (clade 9) has been analyzed in most detail. Their establishment of polarity and asymmetric cleavage requires the differential localization of PAR proteins.
Schulze Jens, Schierenberg Einhard
openaire   +3 more sources