Results 21 to 30 of about 695,954 (267)

Identification of hub genes, signaling pathways and immune infiltration of recurrent spontaneous abortion based on bioinformatics analysis with clinical verification

Taiwanese Journal of Obstetrics & Gynecology, 2022
Objective: The present study was aimed to identify hub genes associated with recurrent spontaneous abortion (RSA) via both bioinformatics analysis and clinical verification, also to evaluate the related pathways and immune infiltration situation of RSA ...
Yun-Xi Chen, Qian-Qian Zhang, Chang Ge, Jing Yang   +3 more
doaj   +1 more source

Ret kinase-mediated mechanical induction of colon stem cells by tumor growth pressure stimulates cancer progression in vivo

Communications Biology, 2022
Ho-Bouldoires, Sollier, Zamfirov and Broders-Bondon et al. show that high frequency pulsatile mechanical stresses maintain the physiological level of mice colon stem cells through the mechanosensitive Ret kinase and that Ret activation is elevated in ...
Thanh Huong Nguyen Ho-Bouldoires, Kévin Sollier, Laura Zamfirov, Florence Broders-Bondon, Démosthène Mitrossilis, Sebastian Bermeo, Coralie L. Guerin, Anna Chipont, Gabriel Champenois, Renaud Leclère, Nicolas André, Laurent Ranno, Aude Michel, Christine Ménager, Didier Meseure, Charlie Demené, Mickael Tanter, Maria Elena Fernández-Sánchez, Emmanuel Farge   +18 more
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Developmental potential of aneuploid human embryos cultured beyond implantation

Nature Communications, 2020
Aneuploidy, abnormal chromosome number, is a major cause of early pregnancy loss. Here the authors determine the extent of post-implantation development of human embryos with common aneuploidies in culture, finding developmental arrest of monosomy 21 ...
Marta N. Shahbazi, Tianren Wang, Xin Tao, Bailey A. T. Weatherbee, Li Sun, Yiping Zhan, Laura Keller, Gary D. Smith, Antonio Pellicer, Richard T. Scott, Emre Seli, Magdalena Zernicka-Goetz   +11 more
doaj   +1 more source

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2

Nature Communications, 2017
Liver and pancreas cells arise from a common endoderm progenitor in the embryo, but what regulates their cell fate is unclear. Here, the authors show that expression of the Three-Amino-acid-Loop-Extension (TALE) homeobox TG-interacting factor 2 (TGIF2 ...
Nuria Cerdá-Esteban, Heike Naumann, Silvia Ruzittu, Nancy Mah, Igor M. Pongrac, Corinna Cozzitorto, Angela Hommel, Miguel A. Andrade-Navarro, Ezio Bonifacio, Francesca M. Spagnoli   +9 more
doaj   +1 more source

Transcription factor OTX2 silences the expression of cleavage embryo genes and transposable elements

The Journal of Reproduction and Development, 2021
Upon mammalian fertilization, zygotic genome activation (ZGA) and activation of transposable elements (TEs) occur in early embryos to establish totipotency and support embryogenesis.
Shi-meng GUO, Ning-hua MEI, Jing YANG, Li-quan ZHOU   +3 more
doaj   +1 more source

Alpha-2-macroglobulin is involved in the occurrence of early-onset pre-eclampsia via its negative impact on uterine spiral artery remodeling and placental angiogenesis

BMC Medicine, 2023
Background Pre-eclampsia (PE) is one of the leading causes of maternal and fetal morbidity/mortality during pregnancy, and alpha-2-macroglobulin (A2M) is associated with inflammatory signaling; however, the pathophysiological mechanism by which A2M is ...
Jingyun Wang, Ping Zhang, Mengyuan Liu, Zhengrui Huang, Xiaofeng Yang, Yuzhen Ding, Jia Liu, Xin Cheng, Shujie Xu, Meiyao He, Fengxiang Zhang, Guang Wang, Ruiman Li, Xuesong Yang   +13 more
doaj   +1 more source

Utilizing Playdoh in the Classroom to Construct a 3D Model Depicting Cellular Movements and Tissue Remodeling during Human Gastrulation, Early Organogenesis, and Embryonic Folding

Journal of Microbiology & Biology Education, 2021
In classroom studies of mammalian embryology, students must fully grasp the cellular and tissue remodeling needed to initiate gastrulation to ensure comprehension of forthcoming developmental processes such as tissue specification and organogenesis ...
Ryan Hesterman, Shannon Rose, Will LeFever, Ryan Stewart, Martina Krone, Camryn Holihan, Kristin Ackerman   +6 more
doaj   +1 more source

Genomic instability in individuals with sex determination defects and germ cell cancer

Cell Death Discovery, 2023
The ability to transmit genetic information through generations depends on the preservation of genome integrity. Genetic abnormalities affect cell differentiation, causing tissue specification defects and cancer.
Maria Krivega, Jutta Zimmer, Anna Slezko, Petra Frank-Herrmann, Julia Rehnitz, Markus Hohenfellner, Markus Bettendorf, Marcin Luzarowski, Thomas Strowitzki   +8 more
doaj   +1 more source

ID3 mediates BMP2-induced downregulation of ICAM1 expression in human endometiral stromal cells and decidual cells

Frontiers in Cell and Developmental Biology, 2023
Recurrent pregnancy loss (RPL) remains an unsolved problem in obstetrics and gynecology, and up to 50% of RPL cases are unexplained. Unexplained RPL (uRPL) is widely considered to be related to an aberrant endometrial microenvironment.
Jin Luo, Jin Luo, Yaqin Wang, Hsun-Ming Chang, Hua Zhu, Jing Yang, Peter C. K. Leung   +6 more
doaj   +1 more source

Identification of early onset pre-eclampsia related key genes via bioinformatic analysis

Informatics in Medicine Unlocked, 2022
Background: Pre-eclampsia is a common pregnancy-specific disease. In this study, we used comprehensive bioinformatics to screen key genes related to the development of pre-eclampsia and explore their potential connections. Methods: Two data sets GSE44711
Zhengrui Huang, Ruiping Chen, Yixuan Zhou, Yiling Wei, Haixia Liu, Ping Zhang, Jingyun Wang, Yuzhen Ding, Xiaofeng Yang, Lu Sun, Meiting Shi, Yudie Gao, Ruiman Li   +12 more
doaj   +1 more source