Results 21 to 30 of about 773,120 (317)

Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors

open access: yesNature Communications, 2018
A role for Slit/Robo signalling in pancreas development has not been defined. Here, the authors generate Robo1/Robo2 knockout mice to identify both as needed for establishing initial pancreatic cell identity as well as for proliferation and survival of ...
Sophie Escot   +4 more
doaj   +1 more source

Epigenetic regulation of germ cell and early embryonic development by Polycomb group proteins [PDF]

open access: yes, 2011
Mammalian development begins at fertilization, when two highly specialized gametes, sperm and oocyte fuse to form a zygote. It is well established that early development of the embryo is driven by factors that are inherited from the oocyte.
Pósfai, Eszter
core   +1 more source

Identification of hub genes, signaling pathways and immune infiltration of recurrent spontaneous abortion based on bioinformatics analysis with clinical verification

open access: yesTaiwanese Journal of Obstetrics & Gynecology, 2022
Objective: The present study was aimed to identify hub genes associated with recurrent spontaneous abortion (RSA) via both bioinformatics analysis and clinical verification, also to evaluate the related pathways and immune infiltration situation of RSA ...
Yun-Xi Chen   +3 more
doaj   +1 more source

Mechanobiology of Embryonic Limb Development [PDF]

open access: yesAnnals of the New York Academy of Sciences, 2007
Abstract:  Considerable evidence exists to support the hypothesis that mechanical forces have an essential role in healthy embryonic skeletal development. Clinical observations and experimental data indicate the importance of muscle contractions for limb development.
Prendergast, Patrick   +2 more
openaire   +4 more sources

Molecular mechanisms separating two axonal pathways during embryonic development of the avian optic tectum [PDF]

open access: yes, 1991
During embryonic development of the avian optic tectum, retinal and tectobulbar axons form an orthogonal array of nerve processes. Growing axons of both tracts are transiently very closely apposed to each other. Despite this spatial proximity, axons from
Kröger, Stephan   +3 more
core   +1 more source

Ret kinase-mediated mechanical induction of colon stem cells by tumor growth pressure stimulates cancer progression in vivo

open access: yesCommunications Biology, 2022
Ho-Bouldoires, Sollier, Zamfirov and Broders-Bondon et al. show that high frequency pulsatile mechanical stresses maintain the physiological level of mice colon stem cells through the mechanosensitive Ret kinase and that Ret activation is elevated in ...
Thanh Huong Nguyen Ho-Bouldoires   +18 more
doaj   +1 more source

Signalling Pathways in Embryonic Development [PDF]

open access: yes, 2018
The formation of a complex multicellular organism from a single cell is one of the most amazing processes of biology. Embryonic development is characterised by the careful regulation of cellular behaviours such that cells proliferate, migrate ...
Stricker, Sigmar   +2 more
core   +1 more source

Developmental potential of aneuploid human embryos cultured beyond implantation

open access: yesNature Communications, 2020
Aneuploidy, abnormal chromosome number, is a major cause of early pregnancy loss. Here the authors determine the extent of post-implantation development of human embryos with common aneuploidies in culture, finding developmental arrest of monosomy 21 ...
Marta N. Shahbazi   +11 more
doaj   +1 more source

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2

open access: yesNature Communications, 2017
Liver and pancreas cells arise from a common endoderm progenitor in the embryo, but what regulates their cell fate is unclear. Here, the authors show that expression of the Three-Amino-acid-Loop-Extension (TALE) homeobox TG-interacting factor 2 (TGIF2 ...
Nuria Cerdá-Esteban   +9 more
doaj   +1 more source

Regulation of the maternal-to-embryonic transition in "C. elegans" [PDF]

open access: yes, 2012
Reproduction is a fundamental process of life which allows the survival of each species through the birth of young species members. Several modes of reproduction evolved and are classified into sexual and asexual reproduction.
Finger, Susanne
core   +1 more source

Home - About - Disclaimer - Privacy