Results 71 to 80 of about 108,196 (262)

Embryo secretome in predicting embryo quality and IVF treatment outcome

Reproductive BioMedicine Online
In IVF treatment, accurate prediction of embryo quality and successful embryo implantation are critical challenges. Recent research has highlighted the importance of the embryo secretome, the collection of molecules secreted by the embryo into the culture medium, in assessing embryo quality as a non-invasive preimplantation testing platform.
Toporcerová, Silvia, Badovská, Zuzana, Kriváková, Eva, Mikulová, Viktória, Mareková, Mária, Altmäe, Signe, Rabajdová, Miroslava   +6 more
openaire   +3 more sources

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A Comprehensive Comparison of PICSI and ICSI Techniques Through a Triple-Blinded Trial: Effects on Embryo Quality, Cumulative Pregnancy Rate, and Live Birth Rate. [PDF]

Biomedicines
Background: Sperm selection is critical in assisted reproduction, typically relying on swim-up and centrifugation density gradients. New methods, such as PICSI (physiological intracytoplasmic sperm selection), aim to enhance outcomes by selecting mature ...
Alegre L, Carrión-Sisternas L, Bori L, Hervás I, Remohí J, Garrido N, Meseguer M.   +6 more
europepmc   +2 more sources

Effect of conjugated linoleic acid on embryo quality in New Zealand rabbits

World Rabbit Science
One of the main challenges in commercial rabbit production is the high nutritional demands in primiparous females, which, together with their limited intake capacity, reduces their body fat stores and could be partly responsible for their low ...
Amada Isabel Osorio-Terán, Wilber Hernández-Montiel, José Abad-Zavaleta, Jacqueline Capataz-Tafur, Victor Manuel Meza-Villlalvazo   +4 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Thyroid ultrasonic changes relate to implantation failure in euthyroid women with thyroid autoimmunity undergoing in vitro fertilization/intracytoplasmic sperm injection

Gynecological Endocrinology
Objective To determine whether ultrasonic manifestations of Hashimoto’s thyroiditis (HT) related to embryo qualities or pregnancy outcomes in women with thyroid autoimmunity (TAI) undergoing in vitro fertilization/intracytoplasmic sperm injection.Methods
Jiahui Wang, Wei Zhou, Jincheng Li, Shuo Zhang, Tong Wu, Zhiyi Song, Chenxi Li, Zengxiang Ma, Yingxin Zhang   +8 more
doaj   +1 more source

Practical Methods to Assess Mammalian Embryo Quality – Staining Tests Comparative Study

Scientific Papers Animal Science and Biotechnologies, 2023
Embryo assessment methods changed during the last 20 years. Morphological criteria used for embryo quality assessment improved in order to increase the selection probability of the most suitable embryos for transfer.
Alexandra Ivan, Nicolae Păcală, Ada Cean, Valeriu Carabă   +3 more
doaj