Results 51 to 60 of about 104,856 (314)

Effects of trigger-day progesterone in the preimplantation genetic testing cycle on the embryo quality and pregnancy outcomes of the subsequent first frozen-thawed blastocyst transfer

Frontiers in Endocrinology, 2023
ObjectiveTo assess whether progesterone (P) levels on the trigger day during preimplantation genetic testing (PGT) cycles are associated with embryo quality and pregnancy outcomes in the subsequent first frozen-thawed blastocyst transfer (FET) cycle ...
Jingdi Li, Jingdi Li, Yueyue Cui, Yueyue Cui, Hao Shi, Hao Shi, Zhiqin Bu, Zhiqin Bu, Fang Wang, Fang Wang, Bo Sun, Bo Sun, Yile Zhang, Yile Zhang   +13 more
doaj   +1 more source

Embryo Aggregation in Pig Improves Cloning Efficiency and Embryo Quality

PLOS ONE, 2016
Dans cette étude, nous avons analysé les effets de l'agrégation d'embryons clonés sur le développement embryonnaire in vitro et la qualité de l'embryon en mesurant le diamètre et le nombre de cellules du blastocyste, les niveaux de fragmentation de l'ADN et l'expression des gènes associés à la pluripotence, à l'apoptose, au trophoblaste et à la ...
C. Buemo, Andrés Gambini, Lucía Moro, M. I. Hiriart, R. Fernández-Martín, Philippe Collas, D. Salamone   +6 more
openaire   +5 more sources

Undernutrition affects embryo quality of superovulated ewes [PDF]

Zygote, 2013
SummaryTo determine the effect of undernutrition on embryo production and quality in superovulated sheep, 45 ewes were allocated into two groups to be fed diets that provided 1.5 (control, C; n = 20) or 0.5 (low nutrition, L; n = 25) times daily requirements for maintenance, from oestrous synchronization with intravaginal sponges to embryo collection ...
J A, Abecia, F, Forcada, I, Palacín, L, Sánchez-Prieto, C, Sosa, A, Fernández-Foren, A, Meikle   +6 more
openaire   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A deep dive into the morphokinetics and ploidy of low-quality blastocysts

F&S Reports, 2022
Objective: To describe morphokinetic parameters and ploidy among low-quality blastocysts not meeting the criteria for clinical use. Design: Prospective cohort study. Setting: Academic medical center.
Molly M. Quinn, M.D., Philip Marsh, M.S., Salustiano Ribeiro, M.S., Rhodel K. Simbulan, M.S., Mitchell P. Rosen, M.D.   +4 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Fertilization and Embryo Development of Fresh and Cryopreserved Sibling Oocytes [PDF]

International Journal of Fertility and Sterility, 2010
Background The pattern of Islamic fasting differs from other forms of fasting, therefore its effect on health also differs. This research studies the effect of Islamic fasting on gonadotropin hormones around the time of the ovulatory cycle and ovulation.
Navid Esfandiar, Murid H. Javed, Zohreh Nazemian, Robert F. Casper   +3 more
doaj   +1 more source

Excellent embryo quality obtained from vitrified oocytes [PDF]

Reproductive BioMedicine Online, 2009
Oocyte vitrification has the potential to expand tremendously the reproductive options for women desiring fertility preservation. Indeed, the number of publications regarding the reliability and efficiency of oocyte vitrification has increased exponentially over the past decade.
William B, Schoolcraft, Jennifer L, Keller, Terry, Schlenker   +2 more
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source